Cdc20: A WD40 Activator for a Cell Cycle Degradation Machine

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Abstract

Cdc20 is an essential cell-cycle regulator required for the completion of mitosis in organisms from yeast to man and contains at its C terminus a WD40 repeat domain that mediates protein-protein interactions. In mitosis, Cdc20 binds to and activates the ubiquitin ligase activity of a large molecular machine called the anaphase-promoting complex/cyclosome (APC/C) and enables the ubiquitination and degradation of securin and cyclin B, thus promoting the onset of anaphase and mitotic exit. APC/CCdc20 is temporally and spatially regulated during the somatic and embryonic cell cycle by numerous mechanisms, including the spindle checkpoint and the cytostatic factor (CSF). Therefore, Cdc20 serves as an integrator of multiple intracellular signaling cascades that regulate progression through mitosis. This review summarizes recent progress toward the understanding of the functions of Cdc20, the mechanisms by which it activates APC/C, and its regulation by phosphorylation and by association with its binding proteins.

Original languageEnglish (US)
Pages (from-to)3-16
Number of pages14
JournalMolecular Cell
Volume27
Issue number1
DOIs
StatePublished - Jul 6 2007

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Mitosis
Anaphase-Promoting Complex-Cyclosome
Cell Cycle
Proto-Oncogene Proteins c-mos
Securin
Protein Interaction Domains and Motifs
Cyclin B
Anaphase
Ubiquitination
Ligases
Ubiquitin
Carrier Proteins
Yeasts
Phosphorylation

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Cdc20 : A WD40 Activator for a Cell Cycle Degradation Machine. / Yu, Hongtao.

In: Molecular Cell, Vol. 27, No. 1, 06.07.2007, p. 3-16.

Research output: Contribution to journalArticle

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