Cdk5 and the mystery of synaptic vesicle endocytosis

Chan Nguyen, James A. Bibb

Research output: Contribution to journalReview article

35 Scopus citations


Regulation of endocytosis by protein phosphorylation and dephosphorylation is critical to synaptic vesicle recycling. Two groups have now identified the neuronal kinase Cdk5 (cyclin-dependent kinase 5) as an important regulator of this process. Robinson and coworkers recently demonstrated that Cdk5 is necessary for synaptic vesicle endocytosis (SVE) (Tan et al., 2003), whereas a new report in this issue claims that Cdk5 negatively regulates SVE (Tomizawa et al., 2003). Careful examination of the data reveals a model that helps resolve the apparently contradictory nature of these reports.

Original languageEnglish (US)
Pages (from-to)697-699
Number of pages3
JournalJournal of Cell Biology
Issue number4
StatePublished - Nov 24 2003

ASJC Scopus subject areas

  • Cell Biology

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