Cefazolin is inferior to cefotetan as single-dose prophylaxis for women undergoing elective total abdominal hysterectomy

David L. Hemsell, Edward R. Johnson, Patricia G. Hemsell, Brenda J. Nobles, Bertis B. Little, Molly C. Heard

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The purpose of this prospective, randomized, double-blind clinical trial was to compare the efficacy of 1-g doses of intravenous cefazolin with that of 1-g doses of intravenous cefotetan in preventing major operative site infections after elective abdominal hysterectomy. A major operative site infection requiring parenteral antimicrobial therapy developed in 46 (9%) of 511 evaluable women: 30 (11.6%) of 258 women given cefazolin prophylaxis and 16 (6.3%) of 253 women given cefotetan prophylaxis (relative risk, 1.84; 95% confidence interval, 1.03 to 3.29; P < .05). Risk factors for major operative site infection were younger age, lower postoperative hemoglobin concentration, and a proliferative endometrium. Ten (3.9%) of 258 women given cefazolin prophylaxis had a postoperative pelvic abscess; two of these women required additional surgical procedures, compared with two (0.8%) of 253 women given cefotetan prophylaxis who had an abscess but did not require surgery (relative risk, 4.9; 95% confidence interval, 1.09 to 22.16; P = .04). A greater number of infections and more serious infections occurred following cefazolin prophylaxis; this treatment resulted in 234 additional hospital days for administration of parenteral antimicrobial therapy.

Original languageEnglish (US)
Pages (from-to)677-684
Number of pages8
JournalClinical Infectious Diseases
Volume20
Issue number3
StatePublished - Mar 1995

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Cefotetan
Cefazolin
Hysterectomy
Infection
Abscess
Confidence Intervals
Hospital Administration
Endometrium
Hemoglobins
Therapeutics
Clinical Trials

ASJC Scopus subject areas

  • Immunology

Cite this

Cefazolin is inferior to cefotetan as single-dose prophylaxis for women undergoing elective total abdominal hysterectomy. / Hemsell, David L.; Johnson, Edward R.; Hemsell, Patricia G.; Nobles, Brenda J.; Little, Bertis B.; Heard, Molly C.

In: Clinical Infectious Diseases, Vol. 20, No. 3, 03.1995, p. 677-684.

Research output: Contribution to journalArticle

Hemsell, David L. ; Johnson, Edward R. ; Hemsell, Patricia G. ; Nobles, Brenda J. ; Little, Bertis B. ; Heard, Molly C. / Cefazolin is inferior to cefotetan as single-dose prophylaxis for women undergoing elective total abdominal hysterectomy. In: Clinical Infectious Diseases. 1995 ; Vol. 20, No. 3. pp. 677-684.
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