Cefotaxime vs. conventional therapy for the treatment of bacterial meningitis of infants and children

C. M. Odio, I. Faingezicht, J. L. Salas, J. Guevara, E. Mohs, G. H. McCracken

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Eighty-five infants and children were prospectively randomized to receive cefotaxime or ampicillin and chloramphenicol for therapy of bacterial meningitis. The two therapy group of patients were compared as to sex, age, clinical status on admission, prior administration of antibiotics and etiology. Three infants (7%) died in each therapy group. Mean number of days of positive cerebrospinal fluid cultures, time to defervescence and duration of treatment and of hospital stay and complications developing during treatment were similar for the two treatment regimens. Median cerebrospinal fluid bactericidal titers against the patients' pathogens in cefotaxime-treated patients (1:64) were larger than those in patients who received conventional therapy (1:8). Mild to moderate motor sequelae were more frequent in those given conventional therapy at the time of discharge only, and not at 4 months or longer of follow-up. We conclude that cefotaxime has similar efficacy when compared with conventional therapy for the management of bacterial meningitis in pediatric patients.

Original languageEnglish (US)
Pages (from-to)402-407
Number of pages6
JournalPediatric Infectious Disease
Volume5
Issue number4
StatePublished - 1986

Fingerprint

Bacterial Meningitides
Cefotaxime
Group Psychotherapy
Therapeutics
Cerebrospinal Fluid
Chloramphenicol
Ampicillin
Length of Stay
Pediatrics
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cefotaxime vs. conventional therapy for the treatment of bacterial meningitis of infants and children. / Odio, C. M.; Faingezicht, I.; Salas, J. L.; Guevara, J.; Mohs, E.; McCracken, G. H.

In: Pediatric Infectious Disease, Vol. 5, No. 4, 1986, p. 402-407.

Research output: Contribution to journalArticle

Odio, C. M. ; Faingezicht, I. ; Salas, J. L. ; Guevara, J. ; Mohs, E. ; McCracken, G. H. / Cefotaxime vs. conventional therapy for the treatment of bacterial meningitis of infants and children. In: Pediatric Infectious Disease. 1986 ; Vol. 5, No. 4. pp. 402-407.
@article{dd54f97b740c42c482428bb17b3dbb9b,
title = "Cefotaxime vs. conventional therapy for the treatment of bacterial meningitis of infants and children",
abstract = "Eighty-five infants and children were prospectively randomized to receive cefotaxime or ampicillin and chloramphenicol for therapy of bacterial meningitis. The two therapy group of patients were compared as to sex, age, clinical status on admission, prior administration of antibiotics and etiology. Three infants (7{\%}) died in each therapy group. Mean number of days of positive cerebrospinal fluid cultures, time to defervescence and duration of treatment and of hospital stay and complications developing during treatment were similar for the two treatment regimens. Median cerebrospinal fluid bactericidal titers against the patients' pathogens in cefotaxime-treated patients (1:64) were larger than those in patients who received conventional therapy (1:8). Mild to moderate motor sequelae were more frequent in those given conventional therapy at the time of discharge only, and not at 4 months or longer of follow-up. We conclude that cefotaxime has similar efficacy when compared with conventional therapy for the management of bacterial meningitis in pediatric patients.",
author = "Odio, {C. M.} and I. Faingezicht and Salas, {J. L.} and J. Guevara and E. Mohs and McCracken, {G. H.}",
year = "1986",
language = "English (US)",
volume = "5",
pages = "402--407",
journal = "Pediatric Infectious Disease Journal",
issn = "0891-3668",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Cefotaxime vs. conventional therapy for the treatment of bacterial meningitis of infants and children

AU - Odio, C. M.

AU - Faingezicht, I.

AU - Salas, J. L.

AU - Guevara, J.

AU - Mohs, E.

AU - McCracken, G. H.

PY - 1986

Y1 - 1986

N2 - Eighty-five infants and children were prospectively randomized to receive cefotaxime or ampicillin and chloramphenicol for therapy of bacterial meningitis. The two therapy group of patients were compared as to sex, age, clinical status on admission, prior administration of antibiotics and etiology. Three infants (7%) died in each therapy group. Mean number of days of positive cerebrospinal fluid cultures, time to defervescence and duration of treatment and of hospital stay and complications developing during treatment were similar for the two treatment regimens. Median cerebrospinal fluid bactericidal titers against the patients' pathogens in cefotaxime-treated patients (1:64) were larger than those in patients who received conventional therapy (1:8). Mild to moderate motor sequelae were more frequent in those given conventional therapy at the time of discharge only, and not at 4 months or longer of follow-up. We conclude that cefotaxime has similar efficacy when compared with conventional therapy for the management of bacterial meningitis in pediatric patients.

AB - Eighty-five infants and children were prospectively randomized to receive cefotaxime or ampicillin and chloramphenicol for therapy of bacterial meningitis. The two therapy group of patients were compared as to sex, age, clinical status on admission, prior administration of antibiotics and etiology. Three infants (7%) died in each therapy group. Mean number of days of positive cerebrospinal fluid cultures, time to defervescence and duration of treatment and of hospital stay and complications developing during treatment were similar for the two treatment regimens. Median cerebrospinal fluid bactericidal titers against the patients' pathogens in cefotaxime-treated patients (1:64) were larger than those in patients who received conventional therapy (1:8). Mild to moderate motor sequelae were more frequent in those given conventional therapy at the time of discharge only, and not at 4 months or longer of follow-up. We conclude that cefotaxime has similar efficacy when compared with conventional therapy for the management of bacterial meningitis in pediatric patients.

UR - http://www.scopus.com/inward/record.url?scp=0022638159&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022638159&partnerID=8YFLogxK

M3 - Article

C2 - 3725653

AN - SCOPUS:0022638159

VL - 5

SP - 402

EP - 407

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

SN - 0891-3668

IS - 4

ER -