Cefoxitin for prophylaxis in premenopausal women undergoing vaginal hysterectomy

D. L. Hemsell, F. G. Cunningham, S. Kappus, B. Nobles

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


To determine the unbiased incidence and types of postoperative infection and their alteration(s) by antimicrobial prophylaxis, a prospective double-blind study was performed using perioperative intramuscular cefoxitin or placebo given to premenopausal women undergoing vaginal hysterectomy at Parkland Memorial Hospital. The clinical and surgical profiles of the 2 groups of women were similar, but there were marked differences in their postoperative clinical courses. Only 8% of the 50 women given cefoxitin had major postoperative infection, compared to 57% of the 49 women given placebo (P<.001); this was associated with a 2.8-day reduction in the hospital stay for those given cefoxitin (P<.001). No clinically significant side effects were observed.

Original languageEnglish (US)
Pages (from-to)629-634
Number of pages6
JournalObstetrics and gynecology
Issue number5
StatePublished - Nov 1980

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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