Cefoxitin serum and uterine concentrations following a two-gram intramuscular dose

D. L. Hemsell, I. Birkett, L. Reveley, J. A. Bland

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Two grams of cefoxitin was administered intramuscularly to 31 premenopausal women when they were called to the operating room for a scheduled vaginal hysterectomy. Serum and tissue samples were obtained to determine cefoxitin concentration. The mean concentration of cefoxitin at the reported peak in serum after an intramuscular injection (30 minutes) was 25.3 μg/ml. The mean serum concentration at the time of uterine excision (a mean of 143 minutes after the on-call dose) was 18.0 μg/ml. The mean concentrations of cefoxitin in the uterine fundus and the lower uterine segment at the time of uterine excision were 1.1 and 1.8 μg/g tissue, respectively.

Original languageEnglish (US)
Pages (from-to)149-152
Number of pages4
JournalObstetrics and gynecology
Volume59
Issue number2
StatePublished - Feb 1982

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Cefoxitin serum and uterine concentrations following a two-gram intramuscular dose'. Together they form a unique fingerprint.

  • Cite this