Ceftriaxone and cefazolin prophylaxis for hysterectomy

D. L. Hemsell, E. R. Johnson, R. E. Bawdon, B. J. Nobles, M. L. Heard

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Two hundred and twenty-five women scheduled for elective hysterectomy were entered into a prospective, comparative, randomized, double-blind clinical trial of antibiotic prophylaxis; 117 had vaginal hysterectomy and 108 had abdominal hysterectomy. They were given a 1 gram preoperative dose of ceftriaxone, an investigational cephalosporin or three 1 gram parenteral doses of cefazolin over a 16 hour period. Antibiotic concentrations were measured in serum and vagina, myometrium, fallopian tube or ovary and mean ceftriaxone concentrations were consistently higher than those of cefazolin. Both regimens were safe, well tolerated and equally effective at preventing major postoperative infection. Diabetes increased the risk for infection regardless of regimen and surgical approach (p = 0.009) and specific risk factors were identified for women undergoing vaginal hysterectomy. The incidence of infection was 1.7% after vaginal hysterectomy, significantly lower than the 7.4% observed after abdominal hysterectomy (p = 0.039). Several of the clinical and surgical variables were identified that could explain this difference.

Original languageEnglish (US)
Pages (from-to)197-203
Number of pages7
JournalSurgery Gynecology and Obstetrics
Volume161
Issue number3
StatePublished - 1985

Fingerprint

Vaginal Hysterectomy
Cefazolin
Ceftriaxone
Hysterectomy
Infection
Antibiotic Prophylaxis
Fallopian Tubes
Myometrium
Vagina
Cephalosporins
Ovary
Clinical Trials
Anti-Bacterial Agents
Incidence
Serum

ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynecology

Cite this

Hemsell, D. L., Johnson, E. R., Bawdon, R. E., Nobles, B. J., & Heard, M. L. (1985). Ceftriaxone and cefazolin prophylaxis for hysterectomy. Surgery Gynecology and Obstetrics, 161(3), 197-203.

Ceftriaxone and cefazolin prophylaxis for hysterectomy. / Hemsell, D. L.; Johnson, E. R.; Bawdon, R. E.; Nobles, B. J.; Heard, M. L.

In: Surgery Gynecology and Obstetrics, Vol. 161, No. 3, 1985, p. 197-203.

Research output: Contribution to journalArticle

Hemsell, DL, Johnson, ER, Bawdon, RE, Nobles, BJ & Heard, ML 1985, 'Ceftriaxone and cefazolin prophylaxis for hysterectomy', Surgery Gynecology and Obstetrics, vol. 161, no. 3, pp. 197-203.
Hemsell DL, Johnson ER, Bawdon RE, Nobles BJ, Heard ML. Ceftriaxone and cefazolin prophylaxis for hysterectomy. Surgery Gynecology and Obstetrics. 1985;161(3):197-203.
Hemsell, D. L. ; Johnson, E. R. ; Bawdon, R. E. ; Nobles, B. J. ; Heard, M. L. / Ceftriaxone and cefazolin prophylaxis for hysterectomy. In: Surgery Gynecology and Obstetrics. 1985 ; Vol. 161, No. 3. pp. 197-203.
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