Ceftriaxone pharmacokinetics in newborn infants

G. H. McCracken, J. D. Siegel, N. Threlkeld, M. Thomas

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Ceftriaxone pharmacokinetics were determined in 40 newborn infants who were 1 to 45 days of age. Mean peak plasma concentrations of 136 to 173 μg/ml were observed at the completion of a 15-min intravenous infusion of 50 mg of ceftriaxone per kg. Mean half-life values were 5.2 to 8.4 h, and mean plasma clearances were 0.7 to 1.8 ml/min. Rectal swab cultures from 14 of 16 infants had either reduced numbers of aerobic and anaerobic bacteria or no growth during therapy. A once-daily dosage schedule is suggested for ceftriaxone therapy in newborn infants.

Original languageEnglish (US)
Pages (from-to)341-343
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume23
Issue number2
StatePublished - 1983

Fingerprint

Ceftriaxone
Pharmacokinetics
Newborn Infant
Aerobic Bacteria
Anaerobic Bacteria
Intravenous Infusions
Half-Life
Appointments and Schedules
Therapeutics
Growth

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

McCracken, G. H., Siegel, J. D., Threlkeld, N., & Thomas, M. (1983). Ceftriaxone pharmacokinetics in newborn infants. Antimicrobial Agents and Chemotherapy, 23(2), 341-343.

Ceftriaxone pharmacokinetics in newborn infants. / McCracken, G. H.; Siegel, J. D.; Threlkeld, N.; Thomas, M.

In: Antimicrobial Agents and Chemotherapy, Vol. 23, No. 2, 1983, p. 341-343.

Research output: Contribution to journalArticle

McCracken, GH, Siegel, JD, Threlkeld, N & Thomas, M 1983, 'Ceftriaxone pharmacokinetics in newborn infants', Antimicrobial Agents and Chemotherapy, vol. 23, no. 2, pp. 341-343.
McCracken, G. H. ; Siegel, J. D. ; Threlkeld, N. ; Thomas, M. / Ceftriaxone pharmacokinetics in newborn infants. In: Antimicrobial Agents and Chemotherapy. 1983 ; Vol. 23, No. 2. pp. 341-343.
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