Ceftriaxone pharmacokinetics in newborn infants

G. H. McCracken, J. D. Siegel, N. Threlkeld, M. Thomas

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Ceftriaxone pharmacokinetics were determined in 40 newborn infants who were 1 to 45 days of age. Mean peak plasma concentrations of 136 to 173 μg/ml were observed at the completion of a 15-min intravenous infusion of 50 mg of ceftriaxone per kg. Mean half-life values were 5.2 to 8.4 h, and mean plasma clearances were 0.7 to 1.8 ml/min. Rectal swab cultures from 14 of 16 infants had either reduced numbers of aerobic and anaerobic bacteria or no growth during therapy. A once-daily dosage schedule is suggested for ceftriaxone therapy in newborn infants.

Original languageEnglish (US)
Pages (from-to)341-343
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume23
Issue number2
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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