Abstract
Ceftriaxone pharmacokinetics were determined in 40 newborn infants who were 1 to 45 days of age. Mean peak plasma concentrations of 136 to 173 μg/ml were observed at the completion of a 15-min intravenous infusion of 50 mg of ceftriaxone per kg. Mean half-life values were 5.2 to 8.4 h, and mean plasma clearances were 0.7 to 1.8 ml/min. Rectal swab cultures from 14 of 16 infants had either reduced numbers of aerobic and anaerobic bacteria or no growth during therapy. A once-daily dosage schedule is suggested for ceftriaxone therapy in newborn infants.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 341-343 |
| Number of pages | 3 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 23 |
| Issue number | 2 |
| State | Published - 1983 |
Fingerprint
ASJC Scopus subject areas
- Pharmacology (medical)
Cite this
Ceftriaxone pharmacokinetics in newborn infants. / McCracken, G. H.; Siegel, J. D.; Threlkeld, N.; Thomas, M.
In: Antimicrobial Agents and Chemotherapy, Vol. 23, No. 2, 1983, p. 341-343.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ceftriaxone pharmacokinetics in newborn infants
AU - McCracken, G. H.
AU - Siegel, J. D.
AU - Threlkeld, N.
AU - Thomas, M.
PY - 1983
Y1 - 1983
N2 - Ceftriaxone pharmacokinetics were determined in 40 newborn infants who were 1 to 45 days of age. Mean peak plasma concentrations of 136 to 173 μg/ml were observed at the completion of a 15-min intravenous infusion of 50 mg of ceftriaxone per kg. Mean half-life values were 5.2 to 8.4 h, and mean plasma clearances were 0.7 to 1.8 ml/min. Rectal swab cultures from 14 of 16 infants had either reduced numbers of aerobic and anaerobic bacteria or no growth during therapy. A once-daily dosage schedule is suggested for ceftriaxone therapy in newborn infants.
AB - Ceftriaxone pharmacokinetics were determined in 40 newborn infants who were 1 to 45 days of age. Mean peak plasma concentrations of 136 to 173 μg/ml were observed at the completion of a 15-min intravenous infusion of 50 mg of ceftriaxone per kg. Mean half-life values were 5.2 to 8.4 h, and mean plasma clearances were 0.7 to 1.8 ml/min. Rectal swab cultures from 14 of 16 infants had either reduced numbers of aerobic and anaerobic bacteria or no growth during therapy. A once-daily dosage schedule is suggested for ceftriaxone therapy in newborn infants.
UR - http://www.scopus.com/inward/record.url?scp=0020691108&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020691108&partnerID=8YFLogxK
M3 - Article
VL - 23
SP - 341
EP - 343
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 2
ER -