Cefuroxime therapy for pneumonia in infants and children.

J. D. Nelson, H. Kusmiesz, S. Shelton

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Because Streptococcus pneumoniae, Haemophilus influenzae b and Staphylococcus aureus are the major causes of bacterial pneumonia in infancy, we customarily have given a beta-lactam antibiotic and chloramphenicol as initial antibiotic therapy. Cefuroxime (75 mg/kg/day divided every 8 hours iv or im) was evaluated as single drug therapy in an open study of 100 infants and children with suspected bacterial pneumonia. The mean serum concentration of cefuroxime 30 minutes after a 15-minute infusion of 25 mg/kg iv was 29.1 micrograms/ml, and the volume of distribution was 695 ml/kg. Pleural fluid concentrations in 3 specimens were 2.2, 8.5 and 11 micrograms/ml. Median age of patients was 15 months. Bacterial etiology was established in 20 patients: H. influenzae b (8 patients); pneumococcus (8 patients); S. aureus (2 patients); Group A streptococcus (1 patient); Neisseria meningitidis B (1 patient). All organisms were susceptible to 1.25-micrograms/ml doses or less of cefuroxime. The mean number of days was 3.1 until patients became afebrile and 5.1 until respiratory symptoms were gone. Eosinophilia occurred in 10 patients. Cefuroxime is safe and effective single drug therapy for pneumonia in infants and children.

Original languageEnglish (US)
Pages (from-to)159-163
Number of pages5
JournalPediatric Infectious Disease
Volume1
Issue number3
StatePublished - May 1982

Fingerprint

Cefuroxime
Pneumonia
Bacterial Pneumonia
Haemophilus influenzae type b
Therapeutics
Streptococcus pneumoniae
Staphylococcus aureus
Anti-Bacterial Agents
Drug Therapy
Neisseria meningitidis
Eosinophilia
beta-Lactams
Chloramphenicol
Streptococcus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cefuroxime therapy for pneumonia in infants and children. / Nelson, J. D.; Kusmiesz, H.; Shelton, S.

In: Pediatric Infectious Disease, Vol. 1, No. 3, 05.1982, p. 159-163.

Research output: Contribution to journalArticle

Nelson, JD, Kusmiesz, H & Shelton, S 1982, 'Cefuroxime therapy for pneumonia in infants and children.', Pediatric Infectious Disease, vol. 1, no. 3, pp. 159-163.
Nelson, J. D. ; Kusmiesz, H. ; Shelton, S. / Cefuroxime therapy for pneumonia in infants and children. In: Pediatric Infectious Disease. 1982 ; Vol. 1, No. 3. pp. 159-163.
@article{816b7b04932a463f85f785344ba69806,
title = "Cefuroxime therapy for pneumonia in infants and children.",
abstract = "Because Streptococcus pneumoniae, Haemophilus influenzae b and Staphylococcus aureus are the major causes of bacterial pneumonia in infancy, we customarily have given a beta-lactam antibiotic and chloramphenicol as initial antibiotic therapy. Cefuroxime (75 mg/kg/day divided every 8 hours iv or im) was evaluated as single drug therapy in an open study of 100 infants and children with suspected bacterial pneumonia. The mean serum concentration of cefuroxime 30 minutes after a 15-minute infusion of 25 mg/kg iv was 29.1 micrograms/ml, and the volume of distribution was 695 ml/kg. Pleural fluid concentrations in 3 specimens were 2.2, 8.5 and 11 micrograms/ml. Median age of patients was 15 months. Bacterial etiology was established in 20 patients: H. influenzae b (8 patients); pneumococcus (8 patients); S. aureus (2 patients); Group A streptococcus (1 patient); Neisseria meningitidis B (1 patient). All organisms were susceptible to 1.25-micrograms/ml doses or less of cefuroxime. The mean number of days was 3.1 until patients became afebrile and 5.1 until respiratory symptoms were gone. Eosinophilia occurred in 10 patients. Cefuroxime is safe and effective single drug therapy for pneumonia in infants and children.",
author = "Nelson, {J. D.} and H. Kusmiesz and S. Shelton",
year = "1982",
month = "5",
language = "English (US)",
volume = "1",
pages = "159--163",
journal = "Pediatric Infectious Disease Journal",
issn = "0891-3668",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Cefuroxime therapy for pneumonia in infants and children.

AU - Nelson, J. D.

AU - Kusmiesz, H.

AU - Shelton, S.

PY - 1982/5

Y1 - 1982/5

N2 - Because Streptococcus pneumoniae, Haemophilus influenzae b and Staphylococcus aureus are the major causes of bacterial pneumonia in infancy, we customarily have given a beta-lactam antibiotic and chloramphenicol as initial antibiotic therapy. Cefuroxime (75 mg/kg/day divided every 8 hours iv or im) was evaluated as single drug therapy in an open study of 100 infants and children with suspected bacterial pneumonia. The mean serum concentration of cefuroxime 30 minutes after a 15-minute infusion of 25 mg/kg iv was 29.1 micrograms/ml, and the volume of distribution was 695 ml/kg. Pleural fluid concentrations in 3 specimens were 2.2, 8.5 and 11 micrograms/ml. Median age of patients was 15 months. Bacterial etiology was established in 20 patients: H. influenzae b (8 patients); pneumococcus (8 patients); S. aureus (2 patients); Group A streptococcus (1 patient); Neisseria meningitidis B (1 patient). All organisms were susceptible to 1.25-micrograms/ml doses or less of cefuroxime. The mean number of days was 3.1 until patients became afebrile and 5.1 until respiratory symptoms were gone. Eosinophilia occurred in 10 patients. Cefuroxime is safe and effective single drug therapy for pneumonia in infants and children.

AB - Because Streptococcus pneumoniae, Haemophilus influenzae b and Staphylococcus aureus are the major causes of bacterial pneumonia in infancy, we customarily have given a beta-lactam antibiotic and chloramphenicol as initial antibiotic therapy. Cefuroxime (75 mg/kg/day divided every 8 hours iv or im) was evaluated as single drug therapy in an open study of 100 infants and children with suspected bacterial pneumonia. The mean serum concentration of cefuroxime 30 minutes after a 15-minute infusion of 25 mg/kg iv was 29.1 micrograms/ml, and the volume of distribution was 695 ml/kg. Pleural fluid concentrations in 3 specimens were 2.2, 8.5 and 11 micrograms/ml. Median age of patients was 15 months. Bacterial etiology was established in 20 patients: H. influenzae b (8 patients); pneumococcus (8 patients); S. aureus (2 patients); Group A streptococcus (1 patient); Neisseria meningitidis B (1 patient). All organisms were susceptible to 1.25-micrograms/ml doses or less of cefuroxime. The mean number of days was 3.1 until patients became afebrile and 5.1 until respiratory symptoms were gone. Eosinophilia occurred in 10 patients. Cefuroxime is safe and effective single drug therapy for pneumonia in infants and children.

UR - http://www.scopus.com/inward/record.url?scp=0020129768&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020129768&partnerID=8YFLogxK

M3 - Article

C2 - 6755404

AN - SCOPUS:0020129768

VL - 1

SP - 159

EP - 163

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

SN - 0891-3668

IS - 3

ER -