Cell autonomy and synchrony of suprachiasmatic nucleus circadian oscillators

Jennifer A. Mohawk, Joseph S. Takahashi

Research output: Contribution to journalReview article

133 Scopus citations

Abstract

The suprachiasmatic nucleus (SCN) of the hypothalamus is the site of the master circadian pacemaker in mammals. The individual cells of the SCN are capable of functioning independently from one another and therefore must form a cohesive circadian network through intercellular coupling. The network properties of the SCN lead to coordination of circadian rhythms among its neurons and neuronal subpopulations. There is increasing evidence for multiple interconnected oscillators within the SCN, and in this review we will highlight recent advances in our knowledge of the complex organization and function of the cellular and network-level SCN clock. Understanding the way in which synchrony is achieved between cells in the SCN will provide insight into the means by which this important nucleus orchestrates circadian rhythms throughout the organism.

Original languageEnglish (US)
Pages (from-to)349-358
Number of pages10
JournalTrends in Neurosciences
Volume34
Issue number7
DOIs
StatePublished - Jul 1 2011

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Cell autonomy and synchrony of suprachiasmatic nucleus circadian oscillators'. Together they form a unique fingerprint.

  • Cite this