Cell autonomy and synchrony of suprachiasmatic nucleus circadian oscillators

Jennifer A. Mohawk, Joseph S. Takahashi

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

The suprachiasmatic nucleus (SCN) of the hypothalamus is the site of the master circadian pacemaker in mammals. The individual cells of the SCN are capable of functioning independently from one another and therefore must form a cohesive circadian network through intercellular coupling. The network properties of the SCN lead to coordination of circadian rhythms among its neurons and neuronal subpopulations. There is increasing evidence for multiple interconnected oscillators within the SCN, and in this review we will highlight recent advances in our knowledge of the complex organization and function of the cellular and network-level SCN clock. Understanding the way in which synchrony is achieved between cells in the SCN will provide insight into the means by which this important nucleus orchestrates circadian rhythms throughout the organism.

Original languageEnglish (US)
Pages (from-to)349-358
Number of pages10
JournalTrends in Neurosciences
Volume34
Issue number7
DOIs
StatePublished - Jul 2011

Fingerprint

Suprachiasmatic Nucleus
Circadian Rhythm
Cell Nucleus
Hypothalamus
Mammals
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cell autonomy and synchrony of suprachiasmatic nucleus circadian oscillators. / Mohawk, Jennifer A.; Takahashi, Joseph S.

In: Trends in Neurosciences, Vol. 34, No. 7, 07.2011, p. 349-358.

Research output: Contribution to journalArticle

@article{b85d8605a1274591bdbeeaca3696b0bb,
title = "Cell autonomy and synchrony of suprachiasmatic nucleus circadian oscillators",
abstract = "The suprachiasmatic nucleus (SCN) of the hypothalamus is the site of the master circadian pacemaker in mammals. The individual cells of the SCN are capable of functioning independently from one another and therefore must form a cohesive circadian network through intercellular coupling. The network properties of the SCN lead to coordination of circadian rhythms among its neurons and neuronal subpopulations. There is increasing evidence for multiple interconnected oscillators within the SCN, and in this review we will highlight recent advances in our knowledge of the complex organization and function of the cellular and network-level SCN clock. Understanding the way in which synchrony is achieved between cells in the SCN will provide insight into the means by which this important nucleus orchestrates circadian rhythms throughout the organism.",
author = "Mohawk, {Jennifer A.} and Takahashi, {Joseph S.}",
year = "2011",
month = "7",
doi = "10.1016/j.tins.2011.05.003",
language = "English (US)",
volume = "34",
pages = "349--358",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Limited",
number = "7",

}

TY - JOUR

T1 - Cell autonomy and synchrony of suprachiasmatic nucleus circadian oscillators

AU - Mohawk, Jennifer A.

AU - Takahashi, Joseph S.

PY - 2011/7

Y1 - 2011/7

N2 - The suprachiasmatic nucleus (SCN) of the hypothalamus is the site of the master circadian pacemaker in mammals. The individual cells of the SCN are capable of functioning independently from one another and therefore must form a cohesive circadian network through intercellular coupling. The network properties of the SCN lead to coordination of circadian rhythms among its neurons and neuronal subpopulations. There is increasing evidence for multiple interconnected oscillators within the SCN, and in this review we will highlight recent advances in our knowledge of the complex organization and function of the cellular and network-level SCN clock. Understanding the way in which synchrony is achieved between cells in the SCN will provide insight into the means by which this important nucleus orchestrates circadian rhythms throughout the organism.

AB - The suprachiasmatic nucleus (SCN) of the hypothalamus is the site of the master circadian pacemaker in mammals. The individual cells of the SCN are capable of functioning independently from one another and therefore must form a cohesive circadian network through intercellular coupling. The network properties of the SCN lead to coordination of circadian rhythms among its neurons and neuronal subpopulations. There is increasing evidence for multiple interconnected oscillators within the SCN, and in this review we will highlight recent advances in our knowledge of the complex organization and function of the cellular and network-level SCN clock. Understanding the way in which synchrony is achieved between cells in the SCN will provide insight into the means by which this important nucleus orchestrates circadian rhythms throughout the organism.

UR - http://www.scopus.com/inward/record.url?scp=79959875504&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959875504&partnerID=8YFLogxK

U2 - 10.1016/j.tins.2011.05.003

DO - 10.1016/j.tins.2011.05.003

M3 - Article

C2 - 21665298

AN - SCOPUS:79959875504

VL - 34

SP - 349

EP - 358

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 7

ER -