Cell contacts in human islets of Langerhans

L. Orci, F. Malaisse-Lagae, M. Amherdt, M. Ravazzola, A. Weisswange, R. Dobbs, A. Perrelet, Roger H Unger

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The freeze fracturing technique was applied to fresh human islets of Langerhans. With this technique, the inside of cellular membranes was revealed, and specific membrane differentiations, hitherto unknown, were observed in the plasma membrane of the endocrine cells. The specific membrane differentiations represent 2 types of intercellular junctions, namely the tight junction, which determines a closure of the extracellular space and the gap junction which allows molecules and ions to diffuse from one cell to another (sharing the gap junction) without leaking in the extracellular space (intercellular coupling). The presence of such junctions may be important for the secretory behavior of the cells within the islet.

Original languageEnglish (US)
Pages (from-to)841-844
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume41
Issue number5
StatePublished - 1975

Fingerprint

Islets of Langerhans
Gap Junctions
Extracellular Space
Membranes
Freeze Fracturing
Cells
Intercellular Junctions
Endocrine Cells
Tight Junctions
Cell membranes
Cell Membrane
Ions
Molecules

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Orci, L., Malaisse-Lagae, F., Amherdt, M., Ravazzola, M., Weisswange, A., Dobbs, R., ... Unger, R. H. (1975). Cell contacts in human islets of Langerhans. Journal of Clinical Endocrinology and Metabolism, 41(5), 841-844.

Cell contacts in human islets of Langerhans. / Orci, L.; Malaisse-Lagae, F.; Amherdt, M.; Ravazzola, M.; Weisswange, A.; Dobbs, R.; Perrelet, A.; Unger, Roger H.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 41, No. 5, 1975, p. 841-844.

Research output: Contribution to journalArticle

Orci, L, Malaisse-Lagae, F, Amherdt, M, Ravazzola, M, Weisswange, A, Dobbs, R, Perrelet, A & Unger, RH 1975, 'Cell contacts in human islets of Langerhans', Journal of Clinical Endocrinology and Metabolism, vol. 41, no. 5, pp. 841-844.
Orci L, Malaisse-Lagae F, Amherdt M, Ravazzola M, Weisswange A, Dobbs R et al. Cell contacts in human islets of Langerhans. Journal of Clinical Endocrinology and Metabolism. 1975;41(5):841-844.
Orci, L. ; Malaisse-Lagae, F. ; Amherdt, M. ; Ravazzola, M. ; Weisswange, A. ; Dobbs, R. ; Perrelet, A. ; Unger, Roger H. / Cell contacts in human islets of Langerhans. In: Journal of Clinical Endocrinology and Metabolism. 1975 ; Vol. 41, No. 5. pp. 841-844.
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