Cell fusion induced by pederine

M. R. Levine, J. Dancis, M. Pavan, R. P. Cox

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Pederine, a natural product extracted from beetles, induces cell fusion among human skin fibroblasts grown in tissue culture. Heterokaryons are produced when pederine is added to mixtures of human diploid fibroblasts and HeLa cells. The efficiency of cell fusion exceeds that achieved with other available agents. The technique is simple and the results are reproducible. Cells exposed to pederine under conditions that cause fusion retain their growth potential, which indicates that the treatment does not damage the cells. The technique should prove useful in research into mechanisms of membrane fusion, as well as research in which cell fusion is used as an investigative tool.

Original languageEnglish (US)
Pages (from-to)606-608
Number of pages3
JournalPediatric Research
Volume8
Issue number5
StatePublished - 1974

Fingerprint

Cell Fusion
Fibroblasts
Membrane Fusion
Beetles
Biological Products
Diploidy
HeLa Cells
Research
Skin
Growth
pederin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Levine, M. R., Dancis, J., Pavan, M., & Cox, R. P. (1974). Cell fusion induced by pederine. Pediatric Research, 8(5), 606-608.

Cell fusion induced by pederine. / Levine, M. R.; Dancis, J.; Pavan, M.; Cox, R. P.

In: Pediatric Research, Vol. 8, No. 5, 1974, p. 606-608.

Research output: Contribution to journalArticle

Levine, MR, Dancis, J, Pavan, M & Cox, RP 1974, 'Cell fusion induced by pederine', Pediatric Research, vol. 8, no. 5, pp. 606-608.
Levine MR, Dancis J, Pavan M, Cox RP. Cell fusion induced by pederine. Pediatric Research. 1974;8(5):606-608.
Levine, M. R. ; Dancis, J. ; Pavan, M. ; Cox, R. P. / Cell fusion induced by pederine. In: Pediatric Research. 1974 ; Vol. 8, No. 5. pp. 606-608.
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