Cell mediated cytotoxicity against HLA-D region products expressed in monocytes and B lymphocytes. III. Inhibition by monoclonal antibodies and study of an HLA-B/DR recombinant

Edward J. Ball, Conleth F. Feighery, Peter Stastny

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Attempts to further define the antigens recognized by HLA-D region specific cytotoxic lymphocytes were undertaken using monocytes and transformed B cell lines as target cells. Monoclonal antibody against framework determinants of HLA-DR antigens partially blocked cell mediated lysis, suggesting that at least a portion of the D-region specific cytotoxic cells recognized the HLA-DR determinants. The study of a family with an HLA-B/DR recombinant showed that the determinants recognized by allogeneic anti-HLA-D-region cytotoxic lymphocytes are encoded outside of HLA-B. In addition, cytotoxic lymphocytes specific for the HLA-D region could be generated with cells identical throughout the interval from HLA-A to B and disparate only to the left of HLA-B.

Original languageEnglish (US)
Pages (from-to)305-313
Number of pages9
JournalHuman Immunology
Volume2
Issue number4
DOIs
StatePublished - Jul 1981

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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