Cell-mediated cytotoxicity against HLA-D-region products expressed in monocytes and B lymphocytes - II. HLA-A- or B-antigen compatibility is not required for HLA-D-region directed cytotoxicity

Conleth F. Feighery, Peter Stastny

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

When effector cells were produced by sensitization in vitro with HLA-A- and B-compatible but HLA-D/DR-incompatible stimulator cells, cytotoxicity apparently was directed against a product of genes closely associated with HLA-D. For effective killing to occur with effector cells against certain minor histocompatibility antigens it is necessary that the effector cells and the target cells be matched for HLA-A or B. We have, therefore, investigated whether sharing of HLA-A or B antigens is needed to obatin efficient lysis with effector cells primed against HLA-D. Good killing was observed with effector cells against HLA-D/DRw3 and against HLA-D/DRw4 whether or not the HLA-A or B antigens were matched. The results indicated that compatibility at HLA-A or B is not required for cell-mediated cytotoxicity against a product of the HLA-D region. The HLA-D region appears to code for products that behave as strong histocompatibility antigens that can by themselves cause cell-mediated killing.

Original languageEnglish (US)
Pages (from-to)39-43
Number of pages5
JournalImmunogenetics
Volume10
Issue number1-4
DOIs
StatePublished - Feb 1980

Fingerprint

HLA-D Antigens
HLA-A Antigens
HLA-B Antigens
Monocytes
B-Lymphocytes
Antigens
Minor Histocompatibility Antigens
Histocompatibility Antigens
HLA-DR Antigens

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

@article{22ff1e79969245edaa2bb4f9385b6b5e,
title = "Cell-mediated cytotoxicity against HLA-D-region products expressed in monocytes and B lymphocytes - II. HLA-A- or B-antigen compatibility is not required for HLA-D-region directed cytotoxicity",
abstract = "When effector cells were produced by sensitization in vitro with HLA-A- and B-compatible but HLA-D/DR-incompatible stimulator cells, cytotoxicity apparently was directed against a product of genes closely associated with HLA-D. For effective killing to occur with effector cells against certain minor histocompatibility antigens it is necessary that the effector cells and the target cells be matched for HLA-A or B. We have, therefore, investigated whether sharing of HLA-A or B antigens is needed to obatin efficient lysis with effector cells primed against HLA-D. Good killing was observed with effector cells against HLA-D/DRw3 and against HLA-D/DRw4 whether or not the HLA-A or B antigens were matched. The results indicated that compatibility at HLA-A or B is not required for cell-mediated cytotoxicity against a product of the HLA-D region. The HLA-D region appears to code for products that behave as strong histocompatibility antigens that can by themselves cause cell-mediated killing.",
author = "Feighery, {Conleth F.} and Peter Stastny",
year = "1980",
month = "2",
doi = "10.1007/BF01561551",
language = "English (US)",
volume = "10",
pages = "39--43",
journal = "Immunogenetics",
issn = "0093-7711",
publisher = "Springer Verlag",
number = "1-4",

}

TY - JOUR

T1 - Cell-mediated cytotoxicity against HLA-D-region products expressed in monocytes and B lymphocytes - II. HLA-A- or B-antigen compatibility is not required for HLA-D-region directed cytotoxicity

AU - Feighery, Conleth F.

AU - Stastny, Peter

PY - 1980/2

Y1 - 1980/2

N2 - When effector cells were produced by sensitization in vitro with HLA-A- and B-compatible but HLA-D/DR-incompatible stimulator cells, cytotoxicity apparently was directed against a product of genes closely associated with HLA-D. For effective killing to occur with effector cells against certain minor histocompatibility antigens it is necessary that the effector cells and the target cells be matched for HLA-A or B. We have, therefore, investigated whether sharing of HLA-A or B antigens is needed to obatin efficient lysis with effector cells primed against HLA-D. Good killing was observed with effector cells against HLA-D/DRw3 and against HLA-D/DRw4 whether or not the HLA-A or B antigens were matched. The results indicated that compatibility at HLA-A or B is not required for cell-mediated cytotoxicity against a product of the HLA-D region. The HLA-D region appears to code for products that behave as strong histocompatibility antigens that can by themselves cause cell-mediated killing.

AB - When effector cells were produced by sensitization in vitro with HLA-A- and B-compatible but HLA-D/DR-incompatible stimulator cells, cytotoxicity apparently was directed against a product of genes closely associated with HLA-D. For effective killing to occur with effector cells against certain minor histocompatibility antigens it is necessary that the effector cells and the target cells be matched for HLA-A or B. We have, therefore, investigated whether sharing of HLA-A or B antigens is needed to obatin efficient lysis with effector cells primed against HLA-D. Good killing was observed with effector cells against HLA-D/DRw3 and against HLA-D/DRw4 whether or not the HLA-A or B antigens were matched. The results indicated that compatibility at HLA-A or B is not required for cell-mediated cytotoxicity against a product of the HLA-D region. The HLA-D region appears to code for products that behave as strong histocompatibility antigens that can by themselves cause cell-mediated killing.

UR - http://www.scopus.com/inward/record.url?scp=0018868304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018868304&partnerID=8YFLogxK

U2 - 10.1007/BF01561551

DO - 10.1007/BF01561551

M3 - Article

VL - 10

SP - 39

EP - 43

JO - Immunogenetics

JF - Immunogenetics

SN - 0093-7711

IS - 1-4

ER -