Cell surface immunoglobulin. XI. The appearance of an IgD like molecule on murine lymphoid cells during ontogeny

E. S. Vitetta, U. Melcher, M. McWilliams, M. E. Lamm, J. M. Phillips-Quagliata, J. W. Uhr

Research output: Contribution to journalArticle

135 Scopus citations

Abstract

An Ig molecule containing L chains and H chains similar to human δ chains was detected on the surface of radioiodinated murine lymphoid cells. Newborn mice have only IgM on their splenocytes. Between 10 and 15 days, the IgD like molecule appears and increases in amount until 3 mth of age, when it is the predominant cell surface Ig in terms of radioactivity. IgD is found only in peripheral lymphoid tissues and is present in larger amounts on peripheral lymph node cells (approximately 85% of surface Ig) than on splenocytes (approximately 50%). IgD is also present in comparable amounts on cells from both nu/nu and germ free mice, indicating that its expression may be independent of both thymic influence and antigenic stimulation. These studies suggest that there is a switch from cell surface IgM to IgD that occurs during differentiation of virgin B lymphocytes in the spleen.

Original languageEnglish (US)
Pages (from-to)206-215
Number of pages10
JournalJournal of Experimental Medicine
Volume141
Issue number1
DOIs
StatePublished - 1975

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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