Cell surface immunoglobulin. XV. The presence of IgM and an IgD like molecule on the same cell in murine lymphoid tissue

E. S. Vitetta, J. W. Uhr

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The present studies were designed to determine whether IgM and 'IgD' are on the same cell in the mouse. Thus, radioiodinated murine lymphocytes were treated with anti μ and complement to kill IgM bearing cells. The dead cells were removed by gradient centrifugation. Results indicate that a portion of the IgD is removed by depleting IgM bearing cells. Using cells from thoracic duct or lymph nodes but not spleen, it was evident that some of the double bearers are large lymphocytes.

Original languageEnglish (US)
Pages (from-to)140-143
Number of pages4
JournalEuropean Journal of Immunology
Volume6
Issue number2
StatePublished - 1976

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Immunoglobulin D
B-Cell Antigen Receptors
Lymphoid Tissue
Immunoglobulin M
Lymphocytes
Thoracic Duct
Centrifugation
Spleen
Lymph Nodes

ASJC Scopus subject areas

  • Immunology

Cite this

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abstract = "The present studies were designed to determine whether IgM and 'IgD' are on the same cell in the mouse. Thus, radioiodinated murine lymphocytes were treated with anti μ and complement to kill IgM bearing cells. The dead cells were removed by gradient centrifugation. Results indicate that a portion of the IgD is removed by depleting IgM bearing cells. Using cells from thoracic duct or lymph nodes but not spleen, it was evident that some of the double bearers are large lymphocytes.",
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