Cell surface immunoglobulin: XVIII. Functional differences of B lymphocytes bearing different surface immunoglobulin isotypes*

E. S. Vitetta, J. Forman, J. R. Kettman

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Three populations of murine splenic B lymphocytes have been characterized previously (6, 7, 9) as those bearing only IgM, those bearing only IgD, and a population bearing both isotypes. These studies were designed to test the response of the IgM+ cells (IgM-only or IgM plus IgD) vs. the IgD-only cells to the B-cell mitogen, lipopolysaccharide. Results suggest that after 1-4 days of culture, in the presence of mitogen, the IgM+ cells enlarge and elaborate an IgM polyclonal response. The IgD-only cells, in contrast, do not exhibit an IgM polyclonal response, but instead undergo blastogenesis and proliferation.

Original languageEnglish (US)
Pages (from-to)1055-1066
Number of pages12
JournalJournal of Experimental Medicine
Volume143
Issue number5
DOIs
StatePublished - May 1 1976

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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