Cell transdifferentiation for neurological disorders: Research progress

Chun Li Pei; Shu Kun Wang; Chun Li Zhang

doi:10.3867/j.issn.1000-3002.2017.11.011

Cell transdifferentiation for neurological disorders: Research progress

Chun Li Pei, Shu Kun Wang, Chun Li Zhang

Research output: Contribution to journal › Article › peer-review

Abstract

Cell transdifferentiation is the direct conversion of one type of cell into another without becoming a pluripotent stem cell. Rapid progress in this field has brought new perspectives on understanding and treating disorders associated with the nervous system, such as neurodegeneration, traumatic injuries, and neuropsychiatric diseases. Being able to obtain functional neurons through trans-differentiation from abundant somatic cells also provides a new strategy for regenerative medicine. In this review we highlight the recent progress in cell transdifferentiation for neurological disorders and discuss potential challenges facing its clinical applications.

Original language	English (US)
Pages (from-to)	1106-1113
Number of pages	8
Journal	Chinese Journal of Pharmacology and Toxicology
Volume	31
Issue number	11
DOIs	https://doi.org/10.3867/j.issn.1000-3002.2017.11.011
State	Published - Nov 2017

Keywords

Neurodegeneration
Neurological disorders
Neuropsychiatric diseases
Transdifferentiation
Traumatic nervous system injury

ASJC Scopus subject areas

Toxicology
Pharmacology

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10.3867/j.issn.1000-3002.2017.11.011

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abstract = "Cell transdifferentiation is the direct conversion of one type of cell into another without becoming a pluripotent stem cell. Rapid progress in this field has brought new perspectives on understanding and treating disorders associated with the nervous system, such as neurodegeneration, traumatic injuries, and neuropsychiatric diseases. Being able to obtain functional neurons through trans-differentiation from abundant somatic cells also provides a new strategy for regenerative medicine. In this review we highlight the recent progress in cell transdifferentiation for neurological disorders and discuss potential challenges facing its clinical applications.",

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AB - Cell transdifferentiation is the direct conversion of one type of cell into another without becoming a pluripotent stem cell. Rapid progress in this field has brought new perspectives on understanding and treating disorders associated with the nervous system, such as neurodegeneration, traumatic injuries, and neuropsychiatric diseases. Being able to obtain functional neurons through trans-differentiation from abundant somatic cells also provides a new strategy for regenerative medicine. In this review we highlight the recent progress in cell transdifferentiation for neurological disorders and discuss potential challenges facing its clinical applications.

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Cell transdifferentiation for neurological disorders: Research progress

Abstract

Keywords

ASJC Scopus subject areas

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