Cell transdifferentiation for neurological disorders: Research progress

Chun Li Pei, Shu Kun Wang, Chun Li Zhang

Research output: Contribution to journalArticle

Abstract

Cell transdifferentiation is the direct conversion of one type of cell into another without becoming a pluripotent stem cell. Rapid progress in this field has brought new perspectives on understanding and treating disorders associated with the nervous system, such as neurodegeneration, traumatic injuries, and neuropsychiatric diseases. Being able to obtain functional neurons through trans-differentiation from abundant somatic cells also provides a new strategy for regenerative medicine. In this review we highlight the recent progress in cell transdifferentiation for neurological disorders and discuss potential challenges facing its clinical applications.

Original languageEnglish (US)
Pages (from-to)1106-1113
Number of pages8
JournalChinese Journal of Pharmacology and Toxicology
Volume31
Issue number11
DOIs
Publication statusPublished - Nov 1 2017

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Keywords

  • Neurodegeneration
  • Neurological disorders
  • Neuropsychiatric diseases
  • Transdifferentiation
  • Traumatic nervous system injury

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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