Cellular and humoral immunity to hepatitis B surface antigen in active chronic hepatitis

W. M. Lee, W. D. Reed, C. G. Mitchell, R. M. Galbraith, A. L. Eddleston, A. J. Zuckerman, R. Williams

Research output: Contribution to journalArticle

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Abstract

The hepatitis B surface antigen (HBsAg) may be persistently present in the serum in a few cases of active chronic hepatitis but the cause of the disease in most patients is unknown. In a study of 39 HBsAg negative cases cell mediated immunity to HBsAg was observed in 24 (62%), suggesting a high frequency of previous infection with the hepatitis B virus. Hepatitis B surface antibody was detectable by radioimmunoassay in 6 patients, in all of whom complexes of HBsAg were present in the serum on electron microscopy. Out of 12 patients with HBsAg positive active chronic hepatitis who were also studied 8, including all those untreated at the time, showed a cellular response to the antigen. Evidence of sensitization to a liver specific cell surface lipoprotein was found with similar frequency in the 2 groups. These results are consistent with the hypothesis that hepatitis B virus infection is important in initiating the disease in many cases of active chronic hepatitis and that sensitization to the liver cell membrane antigen is the autoimmune process responsible for the perpetuation of the liver injury.

Original languageEnglish (US)
Pages (from-to)705-708
Number of pages4
JournalBritish Medical Journal
Volume1
Issue number5960
StatePublished - 1975

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Chronic Hepatitis
Humoral Immunity
Hepatitis B Surface Antigens
Cellular Immunity
Hepatitis B virus
Liver
Hepatitis B Antibodies
Antigens
Virus Diseases
Serum
Lipoproteins
Radioimmunoassay
Electron Microscopy
Cell Membrane
Wounds and Injuries
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lee, W. M., Reed, W. D., Mitchell, C. G., Galbraith, R. M., Eddleston, A. L., Zuckerman, A. J., & Williams, R. (1975). Cellular and humoral immunity to hepatitis B surface antigen in active chronic hepatitis. British Medical Journal, 1(5960), 705-708.

Cellular and humoral immunity to hepatitis B surface antigen in active chronic hepatitis. / Lee, W. M.; Reed, W. D.; Mitchell, C. G.; Galbraith, R. M.; Eddleston, A. L.; Zuckerman, A. J.; Williams, R.

In: British Medical Journal, Vol. 1, No. 5960, 1975, p. 705-708.

Research output: Contribution to journalArticle

Lee, WM, Reed, WD, Mitchell, CG, Galbraith, RM, Eddleston, AL, Zuckerman, AJ & Williams, R 1975, 'Cellular and humoral immunity to hepatitis B surface antigen in active chronic hepatitis', British Medical Journal, vol. 1, no. 5960, pp. 705-708.
Lee WM, Reed WD, Mitchell CG, Galbraith RM, Eddleston AL, Zuckerman AJ et al. Cellular and humoral immunity to hepatitis B surface antigen in active chronic hepatitis. British Medical Journal. 1975;1(5960):705-708.
Lee, W. M. ; Reed, W. D. ; Mitchell, C. G. ; Galbraith, R. M. ; Eddleston, A. L. ; Zuckerman, A. J. ; Williams, R. / Cellular and humoral immunity to hepatitis B surface antigen in active chronic hepatitis. In: British Medical Journal. 1975 ; Vol. 1, No. 5960. pp. 705-708.
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