Cellular differences in protein synthesis regulate tissue homeostasis

Michael Buszczak; Robert A J Signer; Sean J. Morrison

doi:10.1016/j.cell.2014.09.016

Cellular differences in protein synthesis regulate tissue homeostasis

Michael Buszczak, Robert A J Signer, Sean J. Morrison

Research output: Contribution to journal › Review article › peer-review

149 Scopus citations

Abstract

Although sometimes considered a house-keeping function, multiple aspects of protein synthesis are regulated differently among somatic cells, including stem cells, and can be modulated in a cell-type-specific manner. These differences are required to establish and maintain differences in cell identity, cell function, tissue homeostasis, and tumor suppression.

Original language	English (US)
Pages (from-to)	242-251
Number of pages	10
Journal	Cell
Volume	159
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2014.09.016
State	Published - Oct 9 2014

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2014.09.016

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title = "Cellular differences in protein synthesis regulate tissue homeostasis",

abstract = "Although sometimes considered a house-keeping function, multiple aspects of protein synthesis are regulated differently among somatic cells, including stem cells, and can be modulated in a cell-type-specific manner. These differences are required to establish and maintain differences in cell identity, cell function, tissue homeostasis, and tumor suppression.",

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N2 - Although sometimes considered a house-keeping function, multiple aspects of protein synthesis are regulated differently among somatic cells, including stem cells, and can be modulated in a cell-type-specific manner. These differences are required to establish and maintain differences in cell identity, cell function, tissue homeostasis, and tumor suppression.

AB - Although sometimes considered a house-keeping function, multiple aspects of protein synthesis are regulated differently among somatic cells, including stem cells, and can be modulated in a cell-type-specific manner. These differences are required to establish and maintain differences in cell identity, cell function, tissue homeostasis, and tumor suppression.

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Cellular differences in protein synthesis regulate tissue homeostasis

Abstract

ASJC Scopus subject areas

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