TY - JOUR
T1 - Cellular immune response in HIV-infected patients with histoplasmosis
AU - Vail, G. Matthew
AU - Mocherla, Satish
AU - Wheat, L. Joseph
AU - Goldberg, Janet
AU - Camp, April
AU - Brizendine, Edward
AU - Schnizlein-Bick, Carol
PY - 2002/1/1
Y1 - 2002/1/1
N2 - The relationship of immunity to Histoplasma capsulatum and CD4 count in HIV-1-infected patients is unknown. Samples of blood from people with HIV infection and from HIV-negative volunteers were assessed for immune responsiveness to the histoplasmin antigen using proliferation and interferon-γ production as indicators of immunity. Results of histoplasmin skin tests, lymphoproliferative responses (LPR), and interferon-γ production were positive in 9 of 20 (45%) HIV-negative controls, and in vitro measurements agreed highly with skin test reactivity. Among HIV-1-infected patients with recent histoplasmosis, skin test results were positive in none, LPR results were positive in 14%, and interferon-γ production in 18%. Among HIV-1-infected patients with CD4 counts between 200 and 500 cells/mm3, LPR was positive in 8% and interferon-γ production in 33%, and among those with CD4 counts >500 cells/mm3, LPR was positive in 31% and interferon-γ production in 46%. In conclusion, immune responsiveness to H. capsulatum was depressed in HIV-1-infected persons with CD4 counts between 200 and 500 cells/mm3, but approached normal in those with CD4 counts >500 cells/mm3.
AB - The relationship of immunity to Histoplasma capsulatum and CD4 count in HIV-1-infected patients is unknown. Samples of blood from people with HIV infection and from HIV-negative volunteers were assessed for immune responsiveness to the histoplasmin antigen using proliferation and interferon-γ production as indicators of immunity. Results of histoplasmin skin tests, lymphoproliferative responses (LPR), and interferon-γ production were positive in 9 of 20 (45%) HIV-negative controls, and in vitro measurements agreed highly with skin test reactivity. Among HIV-1-infected patients with recent histoplasmosis, skin test results were positive in none, LPR results were positive in 14%, and interferon-γ production in 18%. Among HIV-1-infected patients with CD4 counts between 200 and 500 cells/mm3, LPR was positive in 8% and interferon-γ production in 33%, and among those with CD4 counts >500 cells/mm3, LPR was positive in 31% and interferon-γ production in 46%. In conclusion, immune responsiveness to H. capsulatum was depressed in HIV-1-infected persons with CD4 counts between 200 and 500 cells/mm3, but approached normal in those with CD4 counts >500 cells/mm3.
KW - AIDS
KW - Histoplasmosis
KW - Immunity
KW - Interferon-γ
KW - Lymphoproliferative response
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U2 - 10.1097/00042560-200201010-00006
DO - 10.1097/00042560-200201010-00006
M3 - Article
C2 - 11782589
AN - SCOPUS:0036153840
SN - 1525-4135
VL - 29
SP - 49
EP - 53
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - 1
ER -