Cellular Plasticity in Musculoskeletal Development, Regeneration, and Disease

Deepak A. Kaji; Zhijia Tan; Gemma L. Johnson; Wesley Huang; Kaetlin Vasquez; Jessica A. Lehoczky; Benjamin Levi; Kathryn S.E. Cheah; Alice H. Huang

doi:10.1002/jor.24523

Cellular Plasticity in Musculoskeletal Development, Regeneration, and Disease

Deepak A. Kaji, Zhijia Tan, Gemma L. Johnson, Wesley Huang, Kaetlin Vasquez, Jessica A. Lehoczky, Benjamin Levi, Kathryn S.E. Cheah, Alice H. Huang

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

In this review, we highlight themes from a recent workshop focused on “Plasticity of Cell Fate in Musculoskeletal Tissues” held at the Orthopaedic Research Society's 2019 annual meeting. Experts in the field provided examples of mesenchymal cell plasticity during normal musculoskeletal development, regeneration, and disease. A thorough understanding of the biology underpinning mesenchymal cell plasticity may offer a roadmap for promoting regeneration while attenuating pathologic differentiation.

Original language	English (US)
Pages (from-to)	708-718
Number of pages	11
Journal	Journal of Orthopaedic Research
Volume	38
Issue number	4
DOIs	https://doi.org/10.1002/jor.24523
State	Published - Apr 1 2020
Externally published	Yes

Keywords

heterotopic ossification
mesenchymal plasticity
musculoskeletal development
regeneration
transdifferentiation

ASJC Scopus subject areas

Orthopedics and Sports Medicine

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10.1002/jor.24523

Cite this

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title = "Cellular Plasticity in Musculoskeletal Development, Regeneration, and Disease",

abstract = "In this review, we highlight themes from a recent workshop focused on “Plasticity of Cell Fate in Musculoskeletal Tissues” held at the Orthopaedic Research Society's 2019 annual meeting. Experts in the field provided examples of mesenchymal cell plasticity during normal musculoskeletal development, regeneration, and disease. A thorough understanding of the biology underpinning mesenchymal cell plasticity may offer a roadmap for promoting regeneration while attenuating pathologic differentiation.",

keywords = "heterotopic ossification, mesenchymal plasticity, musculoskeletal development, regeneration, transdifferentiation",

author = "Kaji, {Deepak A.} and Zhijia Tan and Johnson, {Gemma L.} and Wesley Huang and Kaetlin Vasquez and Lehoczky, {Jessica A.} and Benjamin Levi and Cheah, {Kathryn S.E.} and Huang, {Alice H.}",

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year = "2020",

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doi = "10.1002/jor.24523",

language = "English (US)",

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T1 - Cellular Plasticity in Musculoskeletal Development, Regeneration, and Disease

AU - Kaji, Deepak A.

AU - Tan, Zhijia

AU - Johnson, Gemma L.

AU - Huang, Wesley

AU - Vasquez, Kaetlin

AU - Lehoczky, Jessica A.

AU - Levi, Benjamin

AU - Cheah, Kathryn S.E.

AU - Huang, Alice H.

PY - 2020/4/1

Y1 - 2020/4/1

N2 - In this review, we highlight themes from a recent workshop focused on “Plasticity of Cell Fate in Musculoskeletal Tissues” held at the Orthopaedic Research Society's 2019 annual meeting. Experts in the field provided examples of mesenchymal cell plasticity during normal musculoskeletal development, regeneration, and disease. A thorough understanding of the biology underpinning mesenchymal cell plasticity may offer a roadmap for promoting regeneration while attenuating pathologic differentiation.

AB - In this review, we highlight themes from a recent workshop focused on “Plasticity of Cell Fate in Musculoskeletal Tissues” held at the Orthopaedic Research Society's 2019 annual meeting. Experts in the field provided examples of mesenchymal cell plasticity during normal musculoskeletal development, regeneration, and disease. A thorough understanding of the biology underpinning mesenchymal cell plasticity may offer a roadmap for promoting regeneration while attenuating pathologic differentiation.

KW - heterotopic ossification

KW - mesenchymal plasticity

KW - musculoskeletal development

KW - regeneration

KW - transdifferentiation

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JO - Journal of Orthopaedic Research

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ER -

Cellular Plasticity in Musculoskeletal Development, Regeneration, and Disease

Abstract

Keywords

ASJC Scopus subject areas

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