Cellular Plasticity in Musculoskeletal Development, Regeneration, and Disease

Deepak A. Kaji, Zhijia Tan, Gemma L. Johnson, Wesley Huang, Kaetlin Vasquez, Jessica A. Lehoczky, Benjamin Levi, Kathryn S.E. Cheah, Alice H. Huang

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

In this review, we highlight themes from a recent workshop focused on “Plasticity of Cell Fate in Musculoskeletal Tissues” held at the Orthopaedic Research Society's 2019 annual meeting. Experts in the field provided examples of mesenchymal cell plasticity during normal musculoskeletal development, regeneration, and disease. A thorough understanding of the biology underpinning mesenchymal cell plasticity may offer a roadmap for promoting regeneration while attenuating pathologic differentiation.

Original languageEnglish (US)
Pages (from-to)708-718
Number of pages11
JournalJournal of Orthopaedic Research
Volume38
Issue number4
DOIs
StatePublished - Apr 1 2020
Externally publishedYes

Keywords

  • heterotopic ossification
  • mesenchymal plasticity
  • musculoskeletal development
  • regeneration
  • transdifferentiation

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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