Cellular responses to ionizing radiation damage

L. Li, M. Story, R. J. Legerski

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Purpose: The purpose of this report is to provide current perspectives on studies of DNA damage and cell cycle response after ionizing radiation, and their applications in radiation oncology. Methods and Materials: Presentations at the Seventh Annual Radiation Oncology Workshop, held at the International Festival Institute at Round Top, TX, were summarized. Results: Eighteen speakers presented their current work covering a wide range of studies on cellular responses to ionizing radiation. These presentations and discussions form the framework of our report. Conclusion: In response to ionizing radiation, cells immediately activate a series of biochemical pathways that promote cell survival while maintaining genetic integrity. The main cellular defense system against ionizing radiation exposure is composed of two distinct types of biochemical pathways, that is, the DNA damage cell cycle checkpoint pathways and the DNA repair pathways. The DNA damage checkpoint pathways are activated directly by DNA damage, while the repair pathways are constitutively active and are likely modulated by checkpoint signals. Discussions here emphasize that the ATM protein is a central component of the ionizing radiation-responsive pyramid and is essential for activating divergent molecular responses that involve transcriptional regulation, cell cycle arrest, and modulation of DNA repair. The relationship between homologous recombinational repair and nonhomologous end joining of double-strand breaks is also discussed.

Original languageEnglish (US)
Pages (from-to)1157-1162
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Volume49
Issue number4
DOIs
StatePublished - Mar 15 2001

Fingerprint

Ionizing Radiation
radiation damage
ionizing radiation
deoxyribonucleic acid
DNA Damage
Radiation Oncology
damage
Cell Cycle Checkpoints
DNA Repair
cycles
Ataxia Telangiectasia Mutated Proteins
Recombinational DNA Repair
Holidays
asynchronous transfer mode
radiation dosage
radiation
pyramids
Cell Survival
Cell Cycle
strands

Keywords

  • Cell cycle checkpoints
  • DNA repair
  • Ionizing radiation

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Cellular responses to ionizing radiation damage. / Li, L.; Story, M.; Legerski, R. J.

In: International Journal of Radiation Oncology Biology Physics, Vol. 49, No. 4, 15.03.2001, p. 1157-1162.

Research output: Contribution to journalArticle

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