Cellular responses to unsaturated fatty acids mediated by their sensor Ubxd8

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Fatty acids (FAs) are crucial nutrient for cell survival because they are required for synthesis of phospholipids in cellular membranes and for generation of energy. However, overaccumulation of FAs is toxic. In response to excessive FAs, cells are able to activate multiple reactions to prevent their overaccumulation. These reactions are mediated by Ubxd8, a cellular protein that specifically interacts with unsaturated but not saturated FAs. The selective interaction of Ubxd8 with unsaturated FAs may explain previous observations that only unsaturated but not saturated FAs are able to stimulate the regulatory reactions that prevent overaccumulation of FAs. Thus, understanding the mechanism through which Ubxd8 maintains cellular FA homeostasis may provide new insights into saturated FAinduced lipotoxicity.

Original languageEnglish (US)
Pages (from-to)397-403
Number of pages7
JournalFrontiers in Biology
Volume7
Issue number5
DOIs
StatePublished - Oct 18 2012

Keywords

  • Insig-1
  • SREBP
  • Ubxd8
  • fatty acids
  • review
  • triglycerides

ASJC Scopus subject areas

  • Biotechnology
  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Genetics

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