Cellular senescence as a tumor-protection mechanism: The essential role of counting

W. E. Wright, J. W. Shay

Research output: Contribution to journalArticle

250 Citations (Scopus)

Abstract

The term 'cellular senescence' has often been applied indiscriminately to any form of growth arrest of cultured cells that occurs either after some period in culture or following insults such as the overexpression of oncogenes. Recent reports have suggested there may be many mechanisms of cellular senescence. Our increasing understanding of the role of telomere shortening in the replicative aging of cultured fibroblasts now permits a re-examination of what may reasonably be called cellular senescence, and what most likely represents artifacts of the culture environment and/or specific cell-cycle control mechanisms.

Original languageEnglish (US)
Pages (from-to)98-103
Number of pages6
JournalCurrent Opinion in Genetics and Development
Volume11
Issue number1
DOIs
StatePublished - Feb 1 2001

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Cell Aging
Telomere Shortening
Neoplasms
Cell Cycle Checkpoints
Oncogenes
Artifacts
Cultured Cells
Fibroblasts
Growth

ASJC Scopus subject areas

  • Genetics

Cite this

Cellular senescence as a tumor-protection mechanism : The essential role of counting. / Wright, W. E.; Shay, J. W.

In: Current Opinion in Genetics and Development, Vol. 11, No. 1, 01.02.2001, p. 98-103.

Research output: Contribution to journalArticle

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