Cellular uptake of lipoproteins through LRP is apo e dependent

Research output: Contribution to journalArticle

Abstract

We have investigated the role of the low density lipoprotein (LDL) receptor and the LDL receptor related protein (LRP) in the cellular uptake of apoE-enriched lipoproteins. Experiments performed in vitro and in cultured cells involved either 'ligand blotting' or the measurement of apoE dependent cholesterol estrification following uptake of beta-VLDL by normal or LDL receptor deficient human fibroblasts. Our data indicate that ligand binding to LRP in vitro and LRP-dependent beta-VLDL uptake by living cells is absolutely dependent upon the presence of exogenous apoE.

Original languageEnglish (US)
Pages (from-to)71-76
Number of pages6
JournalJournal of Drug Development, Supplement
Volume3
Issue number1
StatePublished - 1990

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Low Density Lipoprotein Receptor-Related Protein-1
Apolipoproteins E
IDL Lipoproteins
Lipoproteins
LDL Receptors
LDL-Receptor Related Proteins
Ligands
Cultured Cells
Fibroblasts
Cholesterol
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology

Cite this

Cellular uptake of lipoproteins through LRP is apo e dependent. / Herz, J.; Kowal, R. C.; Brown, M. S.; Goldstein, J. L.

In: Journal of Drug Development, Supplement, Vol. 3, No. 1, 1990, p. 71-76.

Research output: Contribution to journalArticle

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