Cellular uptake of lipoproteins through LRP is apo e dependent

J. Herz; R. C. Kowal; M. S. Brown; J. L. Goldstein

Cellular uptake of lipoproteins through LRP is apo e dependent

J. Herz, R. C. Kowal, M. S. Brown, J. L. Goldstein

Research output: Contribution to journal › Article › peer-review

Abstract

We have investigated the role of the low density lipoprotein (LDL) receptor and the LDL receptor related protein (LRP) in the cellular uptake of apoE-enriched lipoproteins. Experiments performed in vitro and in cultured cells involved either 'ligand blotting' or the measurement of apoE dependent cholesterol estrification following uptake of beta-VLDL by normal or LDL receptor deficient human fibroblasts. Our data indicate that ligand binding to LRP in vitro and LRP-dependent beta-VLDL uptake by living cells is absolutely dependent upon the presence of exogenous apoE.

Original language	English (US)
Pages (from-to)	71-76
Number of pages	6
Journal	Journal of Drug Development, Supplement
Volume	3
Issue number	1
State	Published - 1990

ASJC Scopus subject areas

Pharmacology

Cite this

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title = "Cellular uptake of lipoproteins through LRP is apo e dependent",

abstract = "We have investigated the role of the low density lipoprotein (LDL) receptor and the LDL receptor related protein (LRP) in the cellular uptake of apoE-enriched lipoproteins. Experiments performed in vitro and in cultured cells involved either 'ligand blotting' or the measurement of apoE dependent cholesterol estrification following uptake of beta-VLDL by normal or LDL receptor deficient human fibroblasts. Our data indicate that ligand binding to LRP in vitro and LRP-dependent beta-VLDL uptake by living cells is absolutely dependent upon the presence of exogenous apoE.",

author = "J. Herz and Kowal, {R. C.} and Brown, {M. S.} and Goldstein, {J. L.}",

year = "1990",

language = "English (US)",

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journal = "Journal of Drug Development, Supplement",

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T1 - Cellular uptake of lipoproteins through LRP is apo e dependent

AU - Herz, J.

AU - Kowal, R. C.

AU - Brown, M. S.

AU - Goldstein, J. L.

PY - 1990

Y1 - 1990

N2 - We have investigated the role of the low density lipoprotein (LDL) receptor and the LDL receptor related protein (LRP) in the cellular uptake of apoE-enriched lipoproteins. Experiments performed in vitro and in cultured cells involved either 'ligand blotting' or the measurement of apoE dependent cholesterol estrification following uptake of beta-VLDL by normal or LDL receptor deficient human fibroblasts. Our data indicate that ligand binding to LRP in vitro and LRP-dependent beta-VLDL uptake by living cells is absolutely dependent upon the presence of exogenous apoE.

AB - We have investigated the role of the low density lipoprotein (LDL) receptor and the LDL receptor related protein (LRP) in the cellular uptake of apoE-enriched lipoproteins. Experiments performed in vitro and in cultured cells involved either 'ligand blotting' or the measurement of apoE dependent cholesterol estrification following uptake of beta-VLDL by normal or LDL receptor deficient human fibroblasts. Our data indicate that ligand binding to LRP in vitro and LRP-dependent beta-VLDL uptake by living cells is absolutely dependent upon the presence of exogenous apoE.

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M3 - Article

AN - SCOPUS:0025043306

SN - 0267-5323

VL - 3

SP - 71

EP - 76

JO - Journal of Drug Development, Supplement

JF - Journal of Drug Development, Supplement

IS - 1

ER -

Cellular uptake of lipoproteins through LRP is apo e dependent

Abstract

ASJC Scopus subject areas

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