Cellular uptake of lipoproteins through LRP is apo e dependent

Research output: Contribution to journalArticlepeer-review

Abstract

We have investigated the role of the low density lipoprotein (LDL) receptor and the LDL receptor related protein (LRP) in the cellular uptake of apoE-enriched lipoproteins. Experiments performed in vitro and in cultured cells involved either 'ligand blotting' or the measurement of apoE dependent cholesterol estrification following uptake of beta-VLDL by normal or LDL receptor deficient human fibroblasts. Our data indicate that ligand binding to LRP in vitro and LRP-dependent beta-VLDL uptake by living cells is absolutely dependent upon the presence of exogenous apoE.

Original languageEnglish (US)
Pages (from-to)71-76
Number of pages6
JournalJournal of Drug Development, Supplement
Volume3
Issue number1
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Pharmacology

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