We have investigated the role of the low density lipoprotein (LDL) receptor and the LDL receptor related protein (LRP) in the cellular uptake of apoE-enriched lipoproteins. Experiments performed in vitro and in cultured cells involved either 'ligand blotting' or the measurement of apoE dependent cholesterol estrification following uptake of beta-VLDL by normal or LDL receptor deficient human fibroblasts. Our data indicate that ligand binding to LRP in vitro and LRP-dependent beta-VLDL uptake by living cells is absolutely dependent upon the presence of exogenous apoE.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of Drug Development, Supplement|
|State||Published - Jan 1 1990|
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