Central nervous control of energy and glucose balance: Focus on the central melanocortin system

Yong Xu, Joel K. Elmquist, Makoto Fukuda

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Studies have suggested that manipulations of the central melanocortin circuitry by pharmacological agents produce robust effects on the regulation of body weight and glucose homeostasis. In this review, we discuss recent findings from genetic mouse models that have further established the physiological relevance of this circuitry in the context of glucose and energy balance. In addition, we will discuss distinct neuronal populations that respond to central melanocortins to regulate food intake, energy expenditure, insulin sensitivity, and insulin secretion, respectively. Finally, multiple hormonal and neural cues (e.g., leptin, estrogen, and serotonin) that use the melanocortin systems to regulate energy and glucose homeostasis will be reviewed. These findings suggest that targeting the specific branches of melanocortin circuits may be potential avenues to combat the current obesity and diabetes epidemics.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalAnnals of the New York Academy of Sciences
Volume1243
Issue number1
DOIs
StatePublished - Dec 2011

Fingerprint

Melanocortins
Glucose
Homeostasis
Insulin
Genetic Models
Medical problems
Leptin
Energy balance
Energy Metabolism
Cues
Insulin Resistance
Serotonin
Estrogens
Obesity
Eating
Body Weight
Pharmacology
Energy
Networks (circuits)
Population

Keywords

  • Body weight
  • Estrogen
  • Leptin
  • Melanocortins
  • Serotonin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Central nervous control of energy and glucose balance : Focus on the central melanocortin system. / Xu, Yong; Elmquist, Joel K.; Fukuda, Makoto.

In: Annals of the New York Academy of Sciences, Vol. 1243, No. 1, 12.2011, p. 1-14.

Research output: Contribution to journalArticle

@article{a65265883d554179b1d5a3ab0edcea3d,
title = "Central nervous control of energy and glucose balance: Focus on the central melanocortin system",
abstract = "Studies have suggested that manipulations of the central melanocortin circuitry by pharmacological agents produce robust effects on the regulation of body weight and glucose homeostasis. In this review, we discuss recent findings from genetic mouse models that have further established the physiological relevance of this circuitry in the context of glucose and energy balance. In addition, we will discuss distinct neuronal populations that respond to central melanocortins to regulate food intake, energy expenditure, insulin sensitivity, and insulin secretion, respectively. Finally, multiple hormonal and neural cues (e.g., leptin, estrogen, and serotonin) that use the melanocortin systems to regulate energy and glucose homeostasis will be reviewed. These findings suggest that targeting the specific branches of melanocortin circuits may be potential avenues to combat the current obesity and diabetes epidemics.",
keywords = "Body weight, Estrogen, Leptin, Melanocortins, Serotonin",
author = "Yong Xu and Elmquist, {Joel K.} and Makoto Fukuda",
year = "2011",
month = "12",
doi = "10.1111/j.1749-6632.2011.06248.x",
language = "English (US)",
volume = "1243",
pages = "1--14",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Central nervous control of energy and glucose balance

T2 - Focus on the central melanocortin system

AU - Xu, Yong

AU - Elmquist, Joel K.

AU - Fukuda, Makoto

PY - 2011/12

Y1 - 2011/12

N2 - Studies have suggested that manipulations of the central melanocortin circuitry by pharmacological agents produce robust effects on the regulation of body weight and glucose homeostasis. In this review, we discuss recent findings from genetic mouse models that have further established the physiological relevance of this circuitry in the context of glucose and energy balance. In addition, we will discuss distinct neuronal populations that respond to central melanocortins to regulate food intake, energy expenditure, insulin sensitivity, and insulin secretion, respectively. Finally, multiple hormonal and neural cues (e.g., leptin, estrogen, and serotonin) that use the melanocortin systems to regulate energy and glucose homeostasis will be reviewed. These findings suggest that targeting the specific branches of melanocortin circuits may be potential avenues to combat the current obesity and diabetes epidemics.

AB - Studies have suggested that manipulations of the central melanocortin circuitry by pharmacological agents produce robust effects on the regulation of body weight and glucose homeostasis. In this review, we discuss recent findings from genetic mouse models that have further established the physiological relevance of this circuitry in the context of glucose and energy balance. In addition, we will discuss distinct neuronal populations that respond to central melanocortins to regulate food intake, energy expenditure, insulin sensitivity, and insulin secretion, respectively. Finally, multiple hormonal and neural cues (e.g., leptin, estrogen, and serotonin) that use the melanocortin systems to regulate energy and glucose homeostasis will be reviewed. These findings suggest that targeting the specific branches of melanocortin circuits may be potential avenues to combat the current obesity and diabetes epidemics.

KW - Body weight

KW - Estrogen

KW - Leptin

KW - Melanocortins

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=84255199265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84255199265&partnerID=8YFLogxK

U2 - 10.1111/j.1749-6632.2011.06248.x

DO - 10.1111/j.1749-6632.2011.06248.x

M3 - Article

C2 - 22211889

AN - SCOPUS:84255199265

VL - 1243

SP - 1

EP - 14

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

IS - 1

ER -