Cerebellar volume loss in radiologically isolated syndrome

Ilena C. George, Mohamed Mounir El Mendili, Matilde Inglese, Christina J. Azevedo, Orhun Kantarci, Christine Lebrun, Axel Siva, Darin T. Okuda, Daniel Pelletier

Research output: Contribution to journalArticle


Radiologically isolated syndrome (RIS), in which asymptomatic demyelinating-appearing lesions are detected incidentally on MRI, can be a pre-clinical form of multiple sclerosis (MS). In this study, we measured cerebellar volumes on 3D T1-weighted 3T MR images in 21 individuals with RIS and 38 age- and sex-matched healthy controls (HC). Normalized cerebellar white matter volume and the anterior cerebellar gray matter volume were significantly decreased in RIS compared to HC (p = 0.003 and p = 0.005, respectively). Our findings support reports of regional brain atrophy in RIS prior to the development of a seminal attack related to inflammatory demyelination.

Original languageEnglish (US)
JournalMultiple Sclerosis Journal
StateAccepted/In press - Jan 1 2019



  • Radiologically isolated syndrome
  • brainstem
  • cerebellar atrophy
  • cerebellum
  • multiple sclerosis
  • white matter lesions

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

George, I. C., El Mendili, M. M., Inglese, M., Azevedo, C. J., Kantarci, O., Lebrun, C., Siva, A., Okuda, D. T., & Pelletier, D. (Accepted/In press). Cerebellar volume loss in radiologically isolated syndrome. Multiple Sclerosis Journal. https://doi.org/10.1177/1352458519887346