Cerebral autoregulation in Alzheimer's disease

Jurgen A H R Claassen, Rong Zhang

Research output: Contribution to journalReview article

60 Scopus citations

Abstract

Cerebral autoregulation aims to stabilize blood flow to the brain during variations in perfusion pressure, thus protecting the brain against the risks of low or high systemic blood pressure. This vital mechanism is severely impaired in the transgenic mouse model of Alzheimer's disease (AD) that abundantly produces amyloid-Β peptide Β 1-42. These observations have been extrapolated to human AD, wherein impairment of autoregulation could have important implications for the clinical management and prevention of AD. Research on cerebral autoregulation in human AD, however, has only recently become available. Contrary to the animal models, preliminary studies suggest that cerebral autoregulation is preserved in patients with AD. Further research is urgently needed to elucidate this discrepancy in the current literature, given the accumulating evidence that implicates cerebrovascular pathology in AD.

Original languageEnglish (US)
Pages (from-to)1572-1577
Number of pages6
JournalJournal of Cerebral Blood Flow and Metabolism
Volume31
Issue number7
DOIs
StatePublished - Jul 1 2011

Keywords

  • cerebral blood flow measurement
  • dementia
  • hypertension
  • infared spectroscopy
  • positron emission tomography
  • transcranial Doppler

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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