Cerebral blood flow during submaximal and maximal dynamic exercise in humans

S. N. Thomas, T. Schroeder, N. H. Secher, J. H. Mitchell

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Abstract

Cerebral blood flow (CBF) in humans was measured at rest and during dynamic exercise on a cycle ergometer corresponding to 56% (range 27-85) of maximal O2 uptake (V̇O(2max)). Exercise bouts were performed by 16 male and female subjects, lasted 15 min each, and were carried out in a semisupine position. CBF (133Xe clearance) was expressed as the initial slope index (ISI) and as the first compartment flow (F1). CBF at rest [ISI, 58 (range 45-73); F1, 76 (rang 55-98) ml · 100 g-1 · min-1] increased during exercise [ISI to 79 (57-94) and F1 to 118 (75-164) ml · 100 g-1 · min-1, P < 0.01]. CBF did not differ significantly between work loads from 32 (24-33) to 86% (74-96) of V̇O(2max) (n = 10). During exercise, mean arterial pressure increased from 84 (60-100) to 101 (78-124) Torr (P < 0.01) and PCO2 remained unchanged [5.1 (4.6-5.6) vs 5.4 (4.4-6.3) kPa, n = 6]. These results demonstrate a median increase of 31% (0-87) in CBF by ISI and a median increase of 58% (0-133) in CBF by F1 during dynamic exercise in humans.

Original languageEnglish (US)
Pages (from-to)744-748
Number of pages5
JournalJournal of Applied Physiology
Volume67
Issue number2
StatePublished - 1989

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Cerebrovascular Circulation
Workload
Arterial Pressure

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Cerebral blood flow during submaximal and maximal dynamic exercise in humans. / Thomas, S. N.; Schroeder, T.; Secher, N. H.; Mitchell, J. H.

In: Journal of Applied Physiology, Vol. 67, No. 2, 1989, p. 744-748.

Research output: Contribution to journalArticle

Thomas, S. N. ; Schroeder, T. ; Secher, N. H. ; Mitchell, J. H. / Cerebral blood flow during submaximal and maximal dynamic exercise in humans. In: Journal of Applied Physiology. 1989 ; Vol. 67, No. 2. pp. 744-748.
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