Abstract
Cerebral blood flow (CBF) in humans was measured at rest and during dynamic exercise on a cycle ergometer corresponding to 56% (range 27-85) of maximal O2 uptake (V̇O(2max)). Exercise bouts were performed by 16 male and female subjects, lasted 15 min each, and were carried out in a semisupine position. CBF (133Xe clearance) was expressed as the initial slope index (ISI) and as the first compartment flow (F1). CBF at rest [ISI, 58 (range 45-73); F1, 76 (rang 55-98) ml · 100 g-1 · min-1] increased during exercise [ISI to 79 (57-94) and F1 to 118 (75-164) ml · 100 g-1 · min-1, P < 0.01]. CBF did not differ significantly between work loads from 32 (24-33) to 86% (74-96) of V̇O(2max) (n = 10). During exercise, mean arterial pressure increased from 84 (60-100) to 101 (78-124) Torr (P < 0.01) and PCO2 remained unchanged [5.1 (4.6-5.6) vs 5.4 (4.4-6.3) kPa, n = 6]. These results demonstrate a median increase of 31% (0-87) in CBF by ISI and a median increase of 58% (0-133) in CBF by F1 during dynamic exercise in humans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 744-748 |
| Number of pages | 5 |
| Journal | Journal of Applied Physiology |
| Volume | 67 |
| Issue number | 2 |
| State | Published - 1989 |
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ASJC Scopus subject areas
- Endocrinology
- Physiology
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
Cerebral blood flow during submaximal and maximal dynamic exercise in humans. / Thomas, S. N.; Schroeder, T.; Secher, N. H.; Mitchell, J. H.
In: Journal of Applied Physiology, Vol. 67, No. 2, 1989, p. 744-748.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebral blood flow during submaximal and maximal dynamic exercise in humans
AU - Thomas, S. N.
AU - Schroeder, T.
AU - Secher, N. H.
AU - Mitchell, J. H.
PY - 1989
Y1 - 1989
N2 - Cerebral blood flow (CBF) in humans was measured at rest and during dynamic exercise on a cycle ergometer corresponding to 56% (range 27-85) of maximal O2 uptake (V̇O(2max)). Exercise bouts were performed by 16 male and female subjects, lasted 15 min each, and were carried out in a semisupine position. CBF (133Xe clearance) was expressed as the initial slope index (ISI) and as the first compartment flow (F1). CBF at rest [ISI, 58 (range 45-73); F1, 76 (rang 55-98) ml · 100 g-1 · min-1] increased during exercise [ISI to 79 (57-94) and F1 to 118 (75-164) ml · 100 g-1 · min-1, P < 0.01]. CBF did not differ significantly between work loads from 32 (24-33) to 86% (74-96) of V̇O(2max) (n = 10). During exercise, mean arterial pressure increased from 84 (60-100) to 101 (78-124) Torr (P < 0.01) and PCO2 remained unchanged [5.1 (4.6-5.6) vs 5.4 (4.4-6.3) kPa, n = 6]. These results demonstrate a median increase of 31% (0-87) in CBF by ISI and a median increase of 58% (0-133) in CBF by F1 during dynamic exercise in humans.
AB - Cerebral blood flow (CBF) in humans was measured at rest and during dynamic exercise on a cycle ergometer corresponding to 56% (range 27-85) of maximal O2 uptake (V̇O(2max)). Exercise bouts were performed by 16 male and female subjects, lasted 15 min each, and were carried out in a semisupine position. CBF (133Xe clearance) was expressed as the initial slope index (ISI) and as the first compartment flow (F1). CBF at rest [ISI, 58 (range 45-73); F1, 76 (rang 55-98) ml · 100 g-1 · min-1] increased during exercise [ISI to 79 (57-94) and F1 to 118 (75-164) ml · 100 g-1 · min-1, P < 0.01]. CBF did not differ significantly between work loads from 32 (24-33) to 86% (74-96) of V̇O(2max) (n = 10). During exercise, mean arterial pressure increased from 84 (60-100) to 101 (78-124) Torr (P < 0.01) and PCO2 remained unchanged [5.1 (4.6-5.6) vs 5.4 (4.4-6.3) kPa, n = 6]. These results demonstrate a median increase of 31% (0-87) in CBF by ISI and a median increase of 58% (0-133) in CBF by F1 during dynamic exercise in humans.
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M3 - Article
VL - 67
SP - 744
EP - 748
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 0161-7567
IS - 2
ER -