Cerebral blood flow modulation insufficiency in brain networks in multiple sclerosis

A hypercapnia MRI study

Olga Marshall, Sanjeev Chawla, Hanzhang Lu, Louise Pape, Yulin Ge

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Cerebrovascular reactivity measures vascular regulation of cerebral blood flow and is responsible for maintaining healthy neurovascular coupling. Multiple sclerosis exhibits progressive neurodegeneration and global cerebrovascular reactivity deficits. This study investigates varied degrees of cerebrovascular reactivity impairment in different brain networks, which may be an underlying cause for functional changes in the brain, affecting long-distance projection integrity and cognitive function; 28 multiple sclerosis and 28 control subjects underwent pseudocontinuous arterial spin labeling perfusion MRI to measure cerebral blood flow under normocapnia (room air) and hypercapnia (5% carbon dioxide gas mixture) breathing. Cerebrovascular reactivity, measured as normocapnic to hypercapnic cerebral blood flow percent increase normalized by end-tidal carbon dioxide change, was determined from seven functional networks (default mode, frontoparietal, somatomotor, visual, limbic, dorsal, and ventral attention networks). Group analysis showed significantly decreased cerebrovascular reactivity in patients compared to controls within the default mode, frontoparietal, somatomotor, and ventral attention networks after multiple comparison correction. Regression analysis showed a significant correlation of cerebrovascular reactivity with lesion load in the default mode and ventral attention networks and with gray matter atrophy in the default mode network. Functional networks in multiple sclerosis patients exhibit varied amounts of cerebrovascular reactivity deficits. Such blood flow regulation abnormalities may contribute to functional communication disruption in multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)2087-2095
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Volume36
Issue number12
DOIs
StatePublished - Dec 1 2016

Fingerprint

Cerebrovascular Circulation
Hypercapnia
Multiple Sclerosis
Brain
Carbon Dioxide
Cognition
Atrophy
Blood Vessels
Respiration
Perfusion
Gases
Communication
Air
Regression Analysis

Keywords

  • Arterial spin labeling
  • brain imaging
  • cerebral blood flow
  • MRI
  • multiple sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Cerebral blood flow modulation insufficiency in brain networks in multiple sclerosis : A hypercapnia MRI study. / Marshall, Olga; Chawla, Sanjeev; Lu, Hanzhang; Pape, Louise; Ge, Yulin.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 36, No. 12, 01.12.2016, p. 2087-2095.

Research output: Contribution to journalArticle

Marshall, Olga ; Chawla, Sanjeev ; Lu, Hanzhang ; Pape, Louise ; Ge, Yulin. / Cerebral blood flow modulation insufficiency in brain networks in multiple sclerosis : A hypercapnia MRI study. In: Journal of Cerebral Blood Flow and Metabolism. 2016 ; Vol. 36, No. 12. pp. 2087-2095.
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