Cerebral Oximetry During Adult Cardiac Surgery Is Associated With Improved Postoperative Outcomes

Karthik Raghunathan, Daryl Kerr, Ying Xian, Grace McCarthy, Robert Habib, Alina Nicoara, Shuaiqi Zhang, J. Scott Rankin, Andrew D. Shaw

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To examine the association/effect of intraoperative cerebral oximetry (CeOx) on major organ morbidity and mortality (MOMM) after adult cardiac surgery. Design: A retrospective, multicenter cohort study. Setting: Patients treated at any hospital within the Society of Thoracic Surgeons Adult Cardiac Surgery Database between July 1, 2011, and December 31, 2016, with a 30-day postoperative follow-up. Participants: Individuals ≥18 years old undergoing isolated coronary artery bypass graft (CABG) or valve repair or replacement, or any combination of procedures with cardiopulmonary bypass. Interventions: Intraoperative CeOx. Measurements and Main Results: MOMM includes operative mortality, stroke, renal failure, prolonged mechanical ventilation, deep sternal wound infection, or reoperation for any reason within 30 days. Of 1.19 million patients who met inclusion criteria within 1,180 facilities, ∼30% (n = 361,124) received CeOx versus nonrecipients (n = 838,675) with similar baseline patient characteristics. Using a propensity score-based 1:1 greedy matching method, 99.7% of CeOx recipients (n = 360,285) were matched with nonrecipients. The rates of MOMM were lower with versus without CeOx. The absolute risk reduction translated to a number needed to treat of 227 patients (95% CI: 166-363, p < 0.0001). In sensitivity analyses of prespecified subgroups, the benefit was strongest among patients undergoing aortic valve repair or replacement ± CABG (more than 7 fewer MOMM events per 1,000, p < 0.0001). However, intensive care unit stay >72 hours was higher with CeOx. Conclusion: Intraoperative cerebral oximetry is associated with less major organ morbidity and mortality after adult cardiac surgery. A large-scale clinical trial is warranted, given that desaturation is common and correctable.

Original languageEnglish (US)
Pages (from-to)3529-3542
Number of pages14
JournalJournal of cardiothoracic and vascular anesthesia
Volume36
Issue number9
DOIs
StatePublished - Sep 2022
Externally publishedYes

Keywords

  • cardiac surgery
  • cerebral oximetry
  • major organ morbidity and mortality
  • STS database

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine

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