CSF dynamics were determined as a function of intracranial pressure in patients with pseudotumor cerebri. Servocontrolled variable rate lumbar infusions were used to determine net CSF-absorptive capacities and resting pressures in 10 patients; serial studies were done in 5 of the patients. Nearly all of the patients had abnormally low CSF-absorptive capacities. On the other hand, marked elevations in resting pressure were not a constant feature of the disease. Concurrent changes in the cerebrovascular bed could introduce errors into this manometric determination of CSF dynamics; the significance of this potential artifact is examined. The results of this study suggest that the CSF compartment may be of etiological importance in the pathophysiology of pseudotumor cerebri.
|Original language||English (US)|
|Number of pages||9|
|Publication status||Published - 1979|
Cerebrospinal fluid dynamics in patients with pseudotumor cerebri. / Sklar, F. H.; Beyer, C. W.; Ramanathan, M.; Cooper, P. R.; Clark, W. K.In: Neurosurgery, Vol. 5, No. 2, 1979, p. 208-216.
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