Cerebrospinal fluid dynamics in patients with pseudotumor cerebri

F. H. Sklar, C. W. Beyer, M. Ramanathan, P. R. Cooper, W. K. Clark

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

CSF dynamics were determined as a function of intracranial pressure in patients with pseudotumor cerebri. Servocontrolled variable rate lumbar infusions were used to determine net CSF-absorptive capacities and resting pressures in 10 patients; serial studies were done in 5 of the patients. Nearly all of the patients had abnormally low CSF-absorptive capacities. On the other hand, marked elevations in resting pressure were not a constant feature of the disease. Concurrent changes in the cerebrovascular bed could introduce errors into this manometric determination of CSF dynamics; the significance of this potential artifact is examined. The results of this study suggest that the CSF compartment may be of etiological importance in the pathophysiology of pseudotumor cerebri.

Original languageEnglish (US)
Pages (from-to)208-216
Number of pages9
JournalUnknown Journal
Volume5
Issue number2
DOIs
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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