Cerebrospinal fluid levels of quinolinic acid in Huntington's disease and schizophrenia

R. Schwarcz, C. A. Tamminga, R. Kurlan, I. Shoulson

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The concentration of the endogenous excitotoxin quinolinic acid was determined in the cerebrospinal fluid of drug-free patients suffering from Huntington's disease or schizophrenia (control group). In both diseases, quinolinic acid concentrations were highly variable (< 4-48 nM) but the mean levels for each disease group were not significantly different from each other or from the quinolinic acid concentration of normal cerebrospinal fluid. Analysis of steady-state cerebrospinal fluid quinolinic acid concentration is unlikely to be of value as a diagnostic tool in Huntington's disease.

Original languageEnglish (US)
Pages (from-to)580-582
Number of pages3
JournalAnnals of Neurology
Volume24
Issue number4
StatePublished - 1988

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Quinolinic Acid
Huntington Disease
Cerebrospinal Fluid
Schizophrenia
Neurotoxins
Control Groups
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cerebrospinal fluid levels of quinolinic acid in Huntington's disease and schizophrenia. / Schwarcz, R.; Tamminga, C. A.; Kurlan, R.; Shoulson, I.

In: Annals of Neurology, Vol. 24, No. 4, 1988, p. 580-582.

Research output: Contribution to journalArticle

Schwarcz, R. ; Tamminga, C. A. ; Kurlan, R. ; Shoulson, I. / Cerebrospinal fluid levels of quinolinic acid in Huntington's disease and schizophrenia. In: Annals of Neurology. 1988 ; Vol. 24, No. 4. pp. 580-582.
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