Cerebrospinal fluid levels of somatostatin, corticotropin‐releasing hormone and corticotropin in alcoholism

A. Roy, J. DeJong, P. Gold, D. Rubinow, B. Adinoff, B. R. Ravitz Waxman, M. Linnoila

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Abstract

Reduced brain and cerebrospinal fluid (CSF) levels of somatostatin, corticotropin‐releasing hormone (CRH) and corticotropin (ACTH) have been reported among neuropsychiatric patients with cognitive dysfunction. Alcoholism is a disorder in which associated neuropsychiatric disorders occur. Therefore, we compared CSF levels of somatostatin, CRH and ACTH in alcoholics (n= 100) and normal controls (n= 30). There were no significant differences between the groups in concentrations of the 3 peptides. Moreover, there were no significant correlations between concentrations of the peptides in CSF and computed tomographic measures of the size of brain ventricles. There were, however, significant correlations between CSF concentrations of CRH and ACTH and between CSF concentrations of CRH and somatostatin in both the alcoholic and control groups.

Original languageEnglish (US)
Pages (from-to)44-48
Number of pages5
JournalActa Psychiatrica Scandinavica
Volume82
Issue number1
DOIs
StatePublished - Jul 1990

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Keywords

  • CSF
  • alcoholism
  • corticotropin
  • corticotropin‐releasing hormone
  • somatostatin

ASJC Scopus subject areas

  • Psychiatry and Mental health

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