Cervical lymph node metastasis in adenoid cystic carcinoma of oral cavity and oropharynx

A collective international review

Carlos Suárez, Leon Barnes, Carl E. Silver, Juan P. Rodrigo, Jatin P. Shah, Asterios Triantafyllou, Alessandra Rinaldo, Antonio Cardesa, Karen T. Pitman, Luiz P. Kowalski, K. Thomas Robbins, Henrik Hellquist, Jesus E. Medina, Remco de Bree, Robert P. Takes, Andrés Coca-Pelaz, Patrick J. Bradley, Douglas R. Gnepp, Afshin Teymoortash, Primož Strojan & 12 others William M. Mendenhall, Jean Anderson Eloy, Justin A. Bishop, Kenneth O. Devaney, Lester D.R. Thompson, Marc Hamoir, Pieter J. Slootweg, Vincent Vander Poorten, Michelle D. Williams, Bruce M. Wenig, Alena Skálová, Alfio Ferlito

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

The purpose of this study was to suggest general guidelines in the management of the N0 neck of oral cavity and oropharyngeal adenoid cystic carcinoma (AdCC) in order to improve the survival of these patients and/or reduce the risk of neck recurrences. The incidence of cervical node metastasis at diagnosis of head and neck AdCC is variable, and ranges between 3% and 16%. Metastasis to the cervical lymph nodes of intraoral and oropharyngeal AdCC varies from 2% to 43%, with the lower rates pertaining to palatal AdCC and the higher rates to base of the tongue. Neck node recurrence may happen after treatment in 0-14% of AdCC, is highly dependent on the extent of the treatment and is very rare in patients who have been treated with therapeutic or elective neck dissections, or elective neck irradiation. Lymph node involvement with or without extracapsular extension in AdCC has been shown in most reports to be independently associated with decreased overall and cause-specific survival, probably because lymph node involvement is a risk factor for subsequent distant metastasis. The overall rate of occult neck metastasis in patients with head and neck AdCC ranges from 15% to 44%, but occult neck metastasis from oral cavity and/or oropharynx seems to occur more frequently than from other locations, such as the sinonasal tract and major salivary glands. Nevertheless, the benefit of elective neck dissection (END) in AdCC is not comparable to that of squamous cell carcinoma, because the main cause of failure is not related to neck or local recurrence, but rather, to distant failure. Therefore, END should be considered in patients with a cN0 neck with AdCC in some high risk oral and oropharyngeal locations when postoperative RT is not planned, or the rare AdCC-high grade transformation.

Original languageEnglish (US)
Pages (from-to)477-484
Number of pages8
JournalAuris Nasus Larynx
Volume43
Issue number5
DOIs
StatePublished - Oct 1 2016

Fingerprint

Adenoid Cystic Carcinoma
Oropharynx
Mouth
Lymph Nodes
Neck
Neoplasm Metastasis
Neck Dissection
Recurrence
Head
Survival
Salivary Glands
Tongue
Squamous Cell Carcinoma
Therapeutics
Guidelines

Keywords

  • Adenoid cystic
  • Carcinoma
  • Lymph nodes
  • Neck dissection
  • Recurrence
  • Risk factors

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

Suárez, C., Barnes, L., Silver, C. E., Rodrigo, J. P., Shah, J. P., Triantafyllou, A., ... Ferlito, A. (2016). Cervical lymph node metastasis in adenoid cystic carcinoma of oral cavity and oropharynx: A collective international review. Auris Nasus Larynx, 43(5), 477-484. https://doi.org/10.1016/j.anl.2016.02.013

Cervical lymph node metastasis in adenoid cystic carcinoma of oral cavity and oropharynx : A collective international review. / Suárez, Carlos; Barnes, Leon; Silver, Carl E.; Rodrigo, Juan P.; Shah, Jatin P.; Triantafyllou, Asterios; Rinaldo, Alessandra; Cardesa, Antonio; Pitman, Karen T.; Kowalski, Luiz P.; Robbins, K. Thomas; Hellquist, Henrik; Medina, Jesus E.; de Bree, Remco; Takes, Robert P.; Coca-Pelaz, Andrés; Bradley, Patrick J.; Gnepp, Douglas R.; Teymoortash, Afshin; Strojan, Primož; Mendenhall, William M.; Eloy, Jean Anderson; Bishop, Justin A.; Devaney, Kenneth O.; Thompson, Lester D.R.; Hamoir, Marc; Slootweg, Pieter J.; Vander Poorten, Vincent; Williams, Michelle D.; Wenig, Bruce M.; Skálová, Alena; Ferlito, Alfio.

In: Auris Nasus Larynx, Vol. 43, No. 5, 01.10.2016, p. 477-484.

Research output: Contribution to journalReview article

Suárez, C, Barnes, L, Silver, CE, Rodrigo, JP, Shah, JP, Triantafyllou, A, Rinaldo, A, Cardesa, A, Pitman, KT, Kowalski, LP, Robbins, KT, Hellquist, H, Medina, JE, de Bree, R, Takes, RP, Coca-Pelaz, A, Bradley, PJ, Gnepp, DR, Teymoortash, A, Strojan, P, Mendenhall, WM, Eloy, JA, Bishop, JA, Devaney, KO, Thompson, LDR, Hamoir, M, Slootweg, PJ, Vander Poorten, V, Williams, MD, Wenig, BM, Skálová, A & Ferlito, A 2016, 'Cervical lymph node metastasis in adenoid cystic carcinoma of oral cavity and oropharynx: A collective international review', Auris Nasus Larynx, vol. 43, no. 5, pp. 477-484. https://doi.org/10.1016/j.anl.2016.02.013
Suárez, Carlos ; Barnes, Leon ; Silver, Carl E. ; Rodrigo, Juan P. ; Shah, Jatin P. ; Triantafyllou, Asterios ; Rinaldo, Alessandra ; Cardesa, Antonio ; Pitman, Karen T. ; Kowalski, Luiz P. ; Robbins, K. Thomas ; Hellquist, Henrik ; Medina, Jesus E. ; de Bree, Remco ; Takes, Robert P. ; Coca-Pelaz, Andrés ; Bradley, Patrick J. ; Gnepp, Douglas R. ; Teymoortash, Afshin ; Strojan, Primož ; Mendenhall, William M. ; Eloy, Jean Anderson ; Bishop, Justin A. ; Devaney, Kenneth O. ; Thompson, Lester D.R. ; Hamoir, Marc ; Slootweg, Pieter J. ; Vander Poorten, Vincent ; Williams, Michelle D. ; Wenig, Bruce M. ; Skálová, Alena ; Ferlito, Alfio. / Cervical lymph node metastasis in adenoid cystic carcinoma of oral cavity and oropharynx : A collective international review. In: Auris Nasus Larynx. 2016 ; Vol. 43, No. 5. pp. 477-484.
@article{a9cfed3f9cc24d19a73439e775ac1ecf,
title = "Cervical lymph node metastasis in adenoid cystic carcinoma of oral cavity and oropharynx: A collective international review",
abstract = "The purpose of this study was to suggest general guidelines in the management of the N0 neck of oral cavity and oropharyngeal adenoid cystic carcinoma (AdCC) in order to improve the survival of these patients and/or reduce the risk of neck recurrences. The incidence of cervical node metastasis at diagnosis of head and neck AdCC is variable, and ranges between 3{\%} and 16{\%}. Metastasis to the cervical lymph nodes of intraoral and oropharyngeal AdCC varies from 2{\%} to 43{\%}, with the lower rates pertaining to palatal AdCC and the higher rates to base of the tongue. Neck node recurrence may happen after treatment in 0-14{\%} of AdCC, is highly dependent on the extent of the treatment and is very rare in patients who have been treated with therapeutic or elective neck dissections, or elective neck irradiation. Lymph node involvement with or without extracapsular extension in AdCC has been shown in most reports to be independently associated with decreased overall and cause-specific survival, probably because lymph node involvement is a risk factor for subsequent distant metastasis. The overall rate of occult neck metastasis in patients with head and neck AdCC ranges from 15{\%} to 44{\%}, but occult neck metastasis from oral cavity and/or oropharynx seems to occur more frequently than from other locations, such as the sinonasal tract and major salivary glands. Nevertheless, the benefit of elective neck dissection (END) in AdCC is not comparable to that of squamous cell carcinoma, because the main cause of failure is not related to neck or local recurrence, but rather, to distant failure. Therefore, END should be considered in patients with a cN0 neck with AdCC in some high risk oral and oropharyngeal locations when postoperative RT is not planned, or the rare AdCC-high grade transformation.",
keywords = "Adenoid cystic, Carcinoma, Lymph nodes, Neck dissection, Recurrence, Risk factors",
author = "Carlos Su{\'a}rez and Leon Barnes and Silver, {Carl E.} and Rodrigo, {Juan P.} and Shah, {Jatin P.} and Asterios Triantafyllou and Alessandra Rinaldo and Antonio Cardesa and Pitman, {Karen T.} and Kowalski, {Luiz P.} and Robbins, {K. Thomas} and Henrik Hellquist and Medina, {Jesus E.} and {de Bree}, Remco and Takes, {Robert P.} and Andr{\'e}s Coca-Pelaz and Bradley, {Patrick J.} and Gnepp, {Douglas R.} and Afshin Teymoortash and Primož Strojan and Mendenhall, {William M.} and Eloy, {Jean Anderson} and Bishop, {Justin A.} and Devaney, {Kenneth O.} and Thompson, {Lester D.R.} and Marc Hamoir and Slootweg, {Pieter J.} and {Vander Poorten}, Vincent and Williams, {Michelle D.} and Wenig, {Bruce M.} and Alena Sk{\'a}lov{\'a} and Alfio Ferlito",
year = "2016",
month = "10",
day = "1",
doi = "10.1016/j.anl.2016.02.013",
language = "English (US)",
volume = "43",
pages = "477--484",
journal = "Auris Nasus Larynx",
issn = "0385-8146",
publisher = "Elsevier Ireland Ltd",
number = "5",

}

TY - JOUR

T1 - Cervical lymph node metastasis in adenoid cystic carcinoma of oral cavity and oropharynx

T2 - A collective international review

AU - Suárez, Carlos

AU - Barnes, Leon

AU - Silver, Carl E.

AU - Rodrigo, Juan P.

AU - Shah, Jatin P.

AU - Triantafyllou, Asterios

AU - Rinaldo, Alessandra

AU - Cardesa, Antonio

AU - Pitman, Karen T.

AU - Kowalski, Luiz P.

AU - Robbins, K. Thomas

AU - Hellquist, Henrik

AU - Medina, Jesus E.

AU - de Bree, Remco

AU - Takes, Robert P.

AU - Coca-Pelaz, Andrés

AU - Bradley, Patrick J.

AU - Gnepp, Douglas R.

AU - Teymoortash, Afshin

AU - Strojan, Primož

AU - Mendenhall, William M.

AU - Eloy, Jean Anderson

AU - Bishop, Justin A.

AU - Devaney, Kenneth O.

AU - Thompson, Lester D.R.

AU - Hamoir, Marc

AU - Slootweg, Pieter J.

AU - Vander Poorten, Vincent

AU - Williams, Michelle D.

AU - Wenig, Bruce M.

AU - Skálová, Alena

AU - Ferlito, Alfio

PY - 2016/10/1

Y1 - 2016/10/1

N2 - The purpose of this study was to suggest general guidelines in the management of the N0 neck of oral cavity and oropharyngeal adenoid cystic carcinoma (AdCC) in order to improve the survival of these patients and/or reduce the risk of neck recurrences. The incidence of cervical node metastasis at diagnosis of head and neck AdCC is variable, and ranges between 3% and 16%. Metastasis to the cervical lymph nodes of intraoral and oropharyngeal AdCC varies from 2% to 43%, with the lower rates pertaining to palatal AdCC and the higher rates to base of the tongue. Neck node recurrence may happen after treatment in 0-14% of AdCC, is highly dependent on the extent of the treatment and is very rare in patients who have been treated with therapeutic or elective neck dissections, or elective neck irradiation. Lymph node involvement with or without extracapsular extension in AdCC has been shown in most reports to be independently associated with decreased overall and cause-specific survival, probably because lymph node involvement is a risk factor for subsequent distant metastasis. The overall rate of occult neck metastasis in patients with head and neck AdCC ranges from 15% to 44%, but occult neck metastasis from oral cavity and/or oropharynx seems to occur more frequently than from other locations, such as the sinonasal tract and major salivary glands. Nevertheless, the benefit of elective neck dissection (END) in AdCC is not comparable to that of squamous cell carcinoma, because the main cause of failure is not related to neck or local recurrence, but rather, to distant failure. Therefore, END should be considered in patients with a cN0 neck with AdCC in some high risk oral and oropharyngeal locations when postoperative RT is not planned, or the rare AdCC-high grade transformation.

AB - The purpose of this study was to suggest general guidelines in the management of the N0 neck of oral cavity and oropharyngeal adenoid cystic carcinoma (AdCC) in order to improve the survival of these patients and/or reduce the risk of neck recurrences. The incidence of cervical node metastasis at diagnosis of head and neck AdCC is variable, and ranges between 3% and 16%. Metastasis to the cervical lymph nodes of intraoral and oropharyngeal AdCC varies from 2% to 43%, with the lower rates pertaining to palatal AdCC and the higher rates to base of the tongue. Neck node recurrence may happen after treatment in 0-14% of AdCC, is highly dependent on the extent of the treatment and is very rare in patients who have been treated with therapeutic or elective neck dissections, or elective neck irradiation. Lymph node involvement with or without extracapsular extension in AdCC has been shown in most reports to be independently associated with decreased overall and cause-specific survival, probably because lymph node involvement is a risk factor for subsequent distant metastasis. The overall rate of occult neck metastasis in patients with head and neck AdCC ranges from 15% to 44%, but occult neck metastasis from oral cavity and/or oropharynx seems to occur more frequently than from other locations, such as the sinonasal tract and major salivary glands. Nevertheless, the benefit of elective neck dissection (END) in AdCC is not comparable to that of squamous cell carcinoma, because the main cause of failure is not related to neck or local recurrence, but rather, to distant failure. Therefore, END should be considered in patients with a cN0 neck with AdCC in some high risk oral and oropharyngeal locations when postoperative RT is not planned, or the rare AdCC-high grade transformation.

KW - Adenoid cystic

KW - Carcinoma

KW - Lymph nodes

KW - Neck dissection

KW - Recurrence

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=84971483876&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84971483876&partnerID=8YFLogxK

U2 - 10.1016/j.anl.2016.02.013

DO - 10.1016/j.anl.2016.02.013

M3 - Review article

VL - 43

SP - 477

EP - 484

JO - Auris Nasus Larynx

JF - Auris Nasus Larynx

SN - 0385-8146

IS - 5

ER -