Challenge and promise: Roles for clusterin in pathogenesis, progression and therapy of cancer

B. Shannan, M. Seifert, K. Leskov, J. Willis, D. Boothman, W. Tilgen, J. Reichrath

Research output: Contribution to journalReview article

256 Scopus citations

Abstract

Clusterin (CLU) has been implicated in various cell functions involved in carcinogenesis and tumour progression. There are two known CLU protein isoforms generated in human cells. A nuclear form of CLU protein (nCLU) is proapoptotic, and a secretory form (sCLU) is prosurvival. CLU expression has been associated with tumorigenesis of various malignancies, including tumours of prostate, colon, and breast. Furthermore, CLU expression is modulated by many factors that are believed to regulate tumour growth and or apoptosis, including 1,25-dihydroxyvitamin D3, transforming growth factor beta-1, ultraviolet radiation, and IR. sCLU upregulation appears to be a general molecular stress response. Presently, preliminary results indicate that therapeutic modalities targeting CLU may be effective in cancer treatment. However, such strategies should make sure that nCLU is not eliminated or reduced. This review summarizes our present understanding of the importance of CLU in various physiological functions including tumour growth, and discusses its relevance to future cancer therapy.

Original languageEnglish (US)
Pages (from-to)12-19
Number of pages8
JournalCell Death and Differentiation
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2006

Keywords

  • Apoptosis
  • Clusterin
  • DNA repair
  • Human tumours
  • nCLU
  • sCLU

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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    Shannan, B., Seifert, M., Leskov, K., Willis, J., Boothman, D., Tilgen, W., & Reichrath, J. (2006). Challenge and promise: Roles for clusterin in pathogenesis, progression and therapy of cancer. Cell Death and Differentiation, 13(1), 12-19. https://doi.org/10.1038/sj.cdd.4401779