TY - JOUR
T1 - Challenge and promise
T2 - Roles for clusterin in pathogenesis, progression and therapy of cancer
AU - Shannan, B.
AU - Seifert, M.
AU - Leskov, K.
AU - Willis, J.
AU - Boothman, D.
AU - Tilgen, W.
AU - Reichrath, J.
PY - 2006/1
Y1 - 2006/1
N2 - Clusterin (CLU) has been implicated in various cell functions involved in carcinogenesis and tumour progression. There are two known CLU protein isoforms generated in human cells. A nuclear form of CLU protein (nCLU) is proapoptotic, and a secretory form (sCLU) is prosurvival. CLU expression has been associated with tumorigenesis of various malignancies, including tumours of prostate, colon, and breast. Furthermore, CLU expression is modulated by many factors that are believed to regulate tumour growth and or apoptosis, including 1,25-dihydroxyvitamin D3, transforming growth factor beta-1, ultraviolet radiation, and IR. sCLU upregulation appears to be a general molecular stress response. Presently, preliminary results indicate that therapeutic modalities targeting CLU may be effective in cancer treatment. However, such strategies should make sure that nCLU is not eliminated or reduced. This review summarizes our present understanding of the importance of CLU in various physiological functions including tumour growth, and discusses its relevance to future cancer therapy.
AB - Clusterin (CLU) has been implicated in various cell functions involved in carcinogenesis and tumour progression. There are two known CLU protein isoforms generated in human cells. A nuclear form of CLU protein (nCLU) is proapoptotic, and a secretory form (sCLU) is prosurvival. CLU expression has been associated with tumorigenesis of various malignancies, including tumours of prostate, colon, and breast. Furthermore, CLU expression is modulated by many factors that are believed to regulate tumour growth and or apoptosis, including 1,25-dihydroxyvitamin D3, transforming growth factor beta-1, ultraviolet radiation, and IR. sCLU upregulation appears to be a general molecular stress response. Presently, preliminary results indicate that therapeutic modalities targeting CLU may be effective in cancer treatment. However, such strategies should make sure that nCLU is not eliminated or reduced. This review summarizes our present understanding of the importance of CLU in various physiological functions including tumour growth, and discusses its relevance to future cancer therapy.
KW - Apoptosis
KW - Clusterin
KW - DNA repair
KW - Human tumours
KW - nCLU
KW - sCLU
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U2 - 10.1038/sj.cdd.4401779
DO - 10.1038/sj.cdd.4401779
M3 - Review article
C2 - 16179938
AN - SCOPUS:33644996125
SN - 1350-9047
VL - 13
SP - 12
EP - 19
JO - Cell Death and Differentiation
JF - Cell Death and Differentiation
IS - 1
ER -