Challenges and Opportunities for Nucleic Acid Therapeutics

David R. Corey, Masad J. Damha, Muthiah Manoharan

Research output: Contribution to journalArticlepeer-review

Abstract

After decades overcoming difficult problems, antisense oligonucleotide (ASO), duplex RNA (siRNA), and messenger RNA (mRNA) nucleic acid therapeutic strategies are finally demonstrating clinical benefits. This success presents new challenges. What goals remain for basic research Will there be an explosion of clinical applications that benefit many patients with different diseases, or will success be restricted to diseases that are ideal for the application of current technologies The aim of this perspective is to describe a selection of the major goals for the next decade.

Original languageEnglish (US)
Pages (from-to)8-13
Number of pages6
JournalNucleic Acid Therapeutics
Volume32
Issue number1
DOIs
StatePublished - Feb 2022
Externally publishedYes

Keywords

  • antisense
  • siRNA
  • therapeutic

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Drug Discovery

Fingerprint

Dive into the research topics of 'Challenges and Opportunities for Nucleic Acid Therapeutics'. Together they form a unique fingerprint.

Cite this