Challenges and opportunities for pediatric severe TBI—review of the evidence and exploring a way forward

for the Investigators of the ADAPT Study

doi:10.1007/s00381-017-3530-y

Challenges and opportunities for pediatric severe TBI—review of the evidence and exploring a way forward

for the Investigators of the ADAPT Study

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Traumatic brain injury (TBI) is a leading killer of children in the developed and developing world. Despite evidence-based guidelines and several recent clinical trials, the progress in developing best practices for children with severe TBI has been slow. This article describes (i) the burden of the disease, (ii) the inadequacies of the evidence-based guidelines, (iii) the failure of the largest clinical trials to prove their primary hypotheses, and (iv) possible advances from an observational cohort study called the Approaches and Decisions for Acute Pediatric TBI (ADAPT) Trial that has recently completed enrollment.

Original language	English (US)
Pages (from-to)	1663-1667
Number of pages	5
Journal	Child's Nervous System
Volume	33
Issue number	10
DOIs	https://doi.org/10.1007/s00381-017-3530-y
State	Published - Oct 1 2017

Keywords

Children
Comparative effectiveness research
Evidenced-based guidelines
Pediatric neurocritical care
Pediatric neurotrauma
Severe traumatic brain injury

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

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10.1007/s00381-017-3530-y

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title = "Challenges and opportunities for pediatric severe TBI—review of the evidence and exploring a way forward",

abstract = "Traumatic brain injury (TBI) is a leading killer of children in the developed and developing world. Despite evidence-based guidelines and several recent clinical trials, the progress in developing best practices for children with severe TBI has been slow. This article describes (i) the burden of the disease, (ii) the inadequacies of the evidence-based guidelines, (iii) the failure of the largest clinical trials to prove their primary hypotheses, and (iv) possible advances from an observational cohort study called the Approaches and Decisions for Acute Pediatric TBI (ADAPT) Trial that has recently completed enrollment.",

keywords = "Children, Comparative effectiveness research, Evidenced-based guidelines, Pediatric neurocritical care, Pediatric neurotrauma, Severe traumatic brain injury",

author = "{for the Investigators of the ADAPT Study} and Bell, {Michael J.} and Adelson, {P. David} and Wisniewski, {Stephen R.} and Shruti Agrawal and Sarah Mahoney and Deepak Gupta and John Beca and Laura Loftis and Kevin Morris and Lauren Piper and Anthony Slater and Karen Walson and Tellen Bennett and Todd Kilbaugh and O{\textquoteright}Meara, {A. M.Iqbal} and Nathan Dean and Chima, {Ranjit S.} and Katherine Biagas and Enno Wildschut and Mark Peters and Kerri LaRovere and Joan Balcells and Courtney Robertson and Shira Gertz and Akash Deep and Sian Cooper and Mark Wainwright and Sarah Murphy and John Kuluz and Warwick Butt and Nicole O{\textquoteright}Brien and Thomas, {Neal J.} and Sandra Buttram and Simon Erickson and Samuel, {J. Mahil} and Rachel Agbeko and Richard Edwards and Ramakrishnan, {Kesava Ananth} and Margaret Winkler and Santiago Borasino and Joanne Natale and Christopher Giza and Mary Hilfiker and David Shellington and Anthony Figaji and Elizabeth Newell and Edward Truemper and Robert Clark and Kit Newth and Michelle Schober",

note = "Publisher Copyright: {\textcopyright} 2017, Springer-Verlag GmbH Germany.",

year = "2017",

month = oct,

day = "1",

doi = "10.1007/s00381-017-3530-y",

language = "English (US)",

volume = "33",

pages = "1663--1667",

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AU - for the Investigators of the ADAPT Study

AU - Bell, Michael J.

AU - Adelson, P. David

AU - Wisniewski, Stephen R.

AU - Agrawal, Shruti

AU - Mahoney, Sarah

AU - Gupta, Deepak

AU - Beca, John

AU - Loftis, Laura

AU - Morris, Kevin

AU - Piper, Lauren

AU - Slater, Anthony

AU - Walson, Karen

AU - Bennett, Tellen

AU - Kilbaugh, Todd

AU - O’Meara, A. M.Iqbal

AU - Dean, Nathan

AU - Chima, Ranjit S.

AU - Biagas, Katherine

AU - Wildschut, Enno

AU - Peters, Mark

AU - LaRovere, Kerri

AU - Balcells, Joan

AU - Robertson, Courtney

AU - Gertz, Shira

AU - Deep, Akash

AU - Cooper, Sian

AU - Wainwright, Mark

AU - Murphy, Sarah

AU - Kuluz, John

AU - Butt, Warwick

AU - O’Brien, Nicole

AU - Thomas, Neal J.

AU - Buttram, Sandra

AU - Erickson, Simon

AU - Samuel, J. Mahil

AU - Agbeko, Rachel

AU - Edwards, Richard

AU - Ramakrishnan, Kesava Ananth

AU - Winkler, Margaret

AU - Borasino, Santiago

AU - Natale, Joanne

AU - Giza, Christopher

AU - Hilfiker, Mary

AU - Shellington, David

AU - Figaji, Anthony

AU - Newell, Elizabeth

AU - Truemper, Edward

AU - Clark, Robert

AU - Newth, Kit

AU - Schober, Michelle

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Traumatic brain injury (TBI) is a leading killer of children in the developed and developing world. Despite evidence-based guidelines and several recent clinical trials, the progress in developing best practices for children with severe TBI has been slow. This article describes (i) the burden of the disease, (ii) the inadequacies of the evidence-based guidelines, (iii) the failure of the largest clinical trials to prove their primary hypotheses, and (iv) possible advances from an observational cohort study called the Approaches and Decisions for Acute Pediatric TBI (ADAPT) Trial that has recently completed enrollment.

AB - Traumatic brain injury (TBI) is a leading killer of children in the developed and developing world. Despite evidence-based guidelines and several recent clinical trials, the progress in developing best practices for children with severe TBI has been slow. This article describes (i) the burden of the disease, (ii) the inadequacies of the evidence-based guidelines, (iii) the failure of the largest clinical trials to prove their primary hypotheses, and (iv) possible advances from an observational cohort study called the Approaches and Decisions for Acute Pediatric TBI (ADAPT) Trial that has recently completed enrollment.

KW - Children

KW - Comparative effectiveness research

KW - Evidenced-based guidelines

KW - Pediatric neurocritical care

KW - Pediatric neurotrauma

KW - Severe traumatic brain injury

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DO - 10.1007/s00381-017-3530-y

M3 - Article

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AN - SCOPUS:85029150855

SN - 0256-7040

VL - 33

SP - 1663

EP - 1667

JO - Child's Nervous System

JF - Child's Nervous System

IS - 10

ER -

Challenges and opportunities for pediatric severe TBI—review of the evidence and exploring a way forward

Abstract

Keywords

ASJC Scopus subject areas

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