Change in argatroban concentration within the vessel wall after local administration using hydrogel-coated balloon catheter

T. Imanishi, M. Arita, K. Shiizaki, H. Ohmori, M. Hamada, T. Hano, I. Nishio, Y. Tomobuchi, K. Nakai

Research output: Contribution to journalArticle

Abstract

Acute coronary occlusion after percutaneous transluminal coronary angioplasty is one of the major problems in coronary intervention. This study evaluated the hydrogel-coated balloon delivery of argatroban to the arterial wall and argatroban persistence after angioplasty in 17 rabbits. A hydrogel- coated balloon was immersed three times in argatroban/saline solution (1 mg/ml) and inflated at 6 arm pressure for 1 min in the common carotid artery. The transfer of argatroban to the vascular wall was measured by high- performance liquid chromatography. The concentrations of argatroban at 0, 5, and 15 min after deflation were 14.8, 4.2, and 3.9 nmole/g · wet weight. The hydrogel-coated balloon catheter can deliver argatroban to the local arterial wall during balloon inflation.

Original languageEnglish (US)
Pages (from-to)267-271
Number of pages5
JournalJournal of Cardiology
Volume27
Issue number5
StatePublished - Jun 28 1996

Keywords

  • anticoagulants
  • blood coagulation
  • drug administration (local drug delivery)
  • hydrogel-coated balloon catheter

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Imanishi, T., Arita, M., Shiizaki, K., Ohmori, H., Hamada, M., Hano, T., Nishio, I., Tomobuchi, Y., & Nakai, K. (1996). Change in argatroban concentration within the vessel wall after local administration using hydrogel-coated balloon catheter. Journal of Cardiology, 27(5), 267-271.