Abstract
Acute coronary occlusion after percutaneous transluminal coronary angioplasty is one of the major problems in coronary intervention. This study evaluated the hydrogel-coated balloon delivery of argatroban to the arterial wall and argatroban persistence after angioplasty in 17 rabbits. A hydrogel- coated balloon was immersed three times in argatroban/saline solution (1 mg/ml) and inflated at 6 arm pressure for 1 min in the common carotid artery. The transfer of argatroban to the vascular wall was measured by high- performance liquid chromatography. The concentrations of argatroban at 0, 5, and 15 min after deflation were 14.8, 4.2, and 3.9 nmole/g · wet weight. The hydrogel-coated balloon catheter can deliver argatroban to the local arterial wall during balloon inflation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 267-271 |
| Number of pages | 5 |
| Journal | Journal of Cardiology |
| Volume | 27 |
| Issue number | 5 |
| State | Published - 1996 |
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Keywords
- anticoagulants
- blood coagulation
- drug administration (local drug delivery)
- hydrogel-coated balloon catheter
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Change in argatroban concentration within the vessel wall after local administration using hydrogel-coated balloon catheter. / Imanishi, T.; Arita, M.; Shiizaki, K.; Ohmori, H.; Hamada, M.; Hano, T.; Nishio, I.; Tomobuchi, Y.; Nakai, K.
In: Journal of Cardiology, Vol. 27, No. 5, 1996, p. 267-271.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Change in argatroban concentration within the vessel wall after local administration using hydrogel-coated balloon catheter
AU - Imanishi, T.
AU - Arita, M.
AU - Shiizaki, K.
AU - Ohmori, H.
AU - Hamada, M.
AU - Hano, T.
AU - Nishio, I.
AU - Tomobuchi, Y.
AU - Nakai, K.
PY - 1996
Y1 - 1996
N2 - Acute coronary occlusion after percutaneous transluminal coronary angioplasty is one of the major problems in coronary intervention. This study evaluated the hydrogel-coated balloon delivery of argatroban to the arterial wall and argatroban persistence after angioplasty in 17 rabbits. A hydrogel- coated balloon was immersed three times in argatroban/saline solution (1 mg/ml) and inflated at 6 arm pressure for 1 min in the common carotid artery. The transfer of argatroban to the vascular wall was measured by high- performance liquid chromatography. The concentrations of argatroban at 0, 5, and 15 min after deflation were 14.8, 4.2, and 3.9 nmole/g · wet weight. The hydrogel-coated balloon catheter can deliver argatroban to the local arterial wall during balloon inflation.
AB - Acute coronary occlusion after percutaneous transluminal coronary angioplasty is one of the major problems in coronary intervention. This study evaluated the hydrogel-coated balloon delivery of argatroban to the arterial wall and argatroban persistence after angioplasty in 17 rabbits. A hydrogel- coated balloon was immersed three times in argatroban/saline solution (1 mg/ml) and inflated at 6 arm pressure for 1 min in the common carotid artery. The transfer of argatroban to the vascular wall was measured by high- performance liquid chromatography. The concentrations of argatroban at 0, 5, and 15 min after deflation were 14.8, 4.2, and 3.9 nmole/g · wet weight. The hydrogel-coated balloon catheter can deliver argatroban to the local arterial wall during balloon inflation.
KW - anticoagulants
KW - blood coagulation
KW - drug administration (local drug delivery)
KW - hydrogel-coated balloon catheter
UR - http://www.scopus.com/inward/record.url?scp=0029886576&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029886576&partnerID=8YFLogxK
M3 - Article
C2 - 8642515
AN - SCOPUS:0029886576
VL - 27
SP - 267
EP - 271
JO - Journal of cardiography. Supplement
JF - Journal of cardiography. Supplement
SN - 0914-5087
IS - 5
ER -