Change in argatroban concentration within the vessel wall after local administration using hydrogel-coated balloon catheter

T. Imanishi, M. Arita, K. Shiizaki, H. Ohmori, M. Hamada, T. Hano, I. Nishio, Y. Tomobuchi, K. Nakai

Research output: Contribution to journalArticle

Abstract

Acute coronary occlusion after percutaneous transluminal coronary angioplasty is one of the major problems in coronary intervention. This study evaluated the hydrogel-coated balloon delivery of argatroban to the arterial wall and argatroban persistence after angioplasty in 17 rabbits. A hydrogel- coated balloon was immersed three times in argatroban/saline solution (1 mg/ml) and inflated at 6 arm pressure for 1 min in the common carotid artery. The transfer of argatroban to the vascular wall was measured by high- performance liquid chromatography. The concentrations of argatroban at 0, 5, and 15 min after deflation were 14.8, 4.2, and 3.9 nmole/g · wet weight. The hydrogel-coated balloon catheter can deliver argatroban to the local arterial wall during balloon inflation.

Original languageEnglish (US)
Pages (from-to)267-271
Number of pages5
JournalJournal of Cardiology
Volume27
Issue number5
StatePublished - 1996

Fingerprint

Hydrogel
Catheters
Coronary Balloon Angioplasty
Coronary Occlusion
Common Carotid Artery
Economic Inflation
Angioplasty
Sodium Chloride
Blood Vessels
argatroban
High Pressure Liquid Chromatography
Rabbits
Pressure
Weights and Measures

Keywords

  • anticoagulants
  • blood coagulation
  • drug administration (local drug delivery)
  • hydrogel-coated balloon catheter

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Imanishi, T., Arita, M., Shiizaki, K., Ohmori, H., Hamada, M., Hano, T., ... Nakai, K. (1996). Change in argatroban concentration within the vessel wall after local administration using hydrogel-coated balloon catheter. Journal of Cardiology, 27(5), 267-271.

Change in argatroban concentration within the vessel wall after local administration using hydrogel-coated balloon catheter. / Imanishi, T.; Arita, M.; Shiizaki, K.; Ohmori, H.; Hamada, M.; Hano, T.; Nishio, I.; Tomobuchi, Y.; Nakai, K.

In: Journal of Cardiology, Vol. 27, No. 5, 1996, p. 267-271.

Research output: Contribution to journalArticle

Imanishi, T, Arita, M, Shiizaki, K, Ohmori, H, Hamada, M, Hano, T, Nishio, I, Tomobuchi, Y & Nakai, K 1996, 'Change in argatroban concentration within the vessel wall after local administration using hydrogel-coated balloon catheter', Journal of Cardiology, vol. 27, no. 5, pp. 267-271.
Imanishi, T. ; Arita, M. ; Shiizaki, K. ; Ohmori, H. ; Hamada, M. ; Hano, T. ; Nishio, I. ; Tomobuchi, Y. ; Nakai, K. / Change in argatroban concentration within the vessel wall after local administration using hydrogel-coated balloon catheter. In: Journal of Cardiology. 1996 ; Vol. 27, No. 5. pp. 267-271.
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