Changes in caudate volume with neuroleptic treatment

MatcheriS Keshavan; WernerW Bagwell; GretchenL Haas; JohnA Sweeney; NinaR Schooler; JayW Pettegrew

doi:10.1016/S0140-6736(94)90599-1

Changes in caudate volume with neuroleptic treatment

MatcheriS Keshavan, WernerW Bagwell, GretchenL Haas, JohnA Sweeney, NinaR Schooler, JayW Pettegrew

Research output: Contribution to journal › Letter › peer-review

Original language	English (US)
Pages (from-to)	1434
Number of pages	1
Journal	The Lancet
Volume	344
Issue number	8934
DOIs	https://doi.org/10.1016/S0140-6736(94)90599-1
State	Published - Nov 19 1994

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(94)90599-1

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@article{c4c6423645ef40aeb0f0ec5fd2259927,

title = "Changes in caudate volume with neuroleptic treatment",

author = "MatcheriS Keshavan and WernerW Bagwell and GretchenL Haas and JohnA Sweeney and NinaR Schooler and JayW Pettegrew",

note = "Funding Information: changes may also result from regenerative collateral sprouting of striatal neurons causing volume increases.{\textquoteright} The clinical significance of the observed volume increase needs to be studied. Such alterations in caudate nucleus volume may not be caused by the {"}atypical{\textquoteright} antipsychotic drugs, such as clozapine, which have a smaller effect on striatal D2 receptor occupancy.s Future studies need to tease apart the effects of continuing illness versus those of treatment with typical and atypical antipsychotic drugs on the anatomy of the corpus striatum and their relation, if any, to the development of long term extrapyramidal sequelae such as tardive dyskinesia. Supported by National Institute of Mental Health Grants 45203, 45156, and 44614. We than! Dr Susan Sesack for her helpful comments and Sadia Zafar for help in data collection.",

year = "1994",

month = nov,

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doi = "10.1016/S0140-6736(94)90599-1",

language = "English (US)",

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TY - JOUR

T1 - Changes in caudate volume with neuroleptic treatment

AU - Keshavan, MatcheriS

AU - Bagwell, WernerW

AU - Haas, GretchenL

AU - Sweeney, JohnA

AU - Schooler, NinaR

AU - Pettegrew, JayW

N1 - Funding Information: changes may also result from regenerative collateral sprouting of striatal neurons causing volume increases.’ The clinical significance of the observed volume increase needs to be studied. Such alterations in caudate nucleus volume may not be caused by the "atypical’ antipsychotic drugs, such as clozapine, which have a smaller effect on striatal D2 receptor occupancy.s Future studies need to tease apart the effects of continuing illness versus those of treatment with typical and atypical antipsychotic drugs on the anatomy of the corpus striatum and their relation, if any, to the development of long term extrapyramidal sequelae such as tardive dyskinesia. Supported by National Institute of Mental Health Grants 45203, 45156, and 44614. We than! Dr Susan Sesack for her helpful comments and Sadia Zafar for help in data collection.

PY - 1994/11/19

Y1 - 1994/11/19

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U2 - 10.1016/S0140-6736(94)90599-1

DO - 10.1016/S0140-6736(94)90599-1

M3 - Letter

C2 - 7968091

AN - SCOPUS:0028104623

SN - 0140-6736

VL - 344

SP - 1434

JO - The Lancet

JF - The Lancet

IS - 8934

ER -

Changes in caudate volume with neuroleptic treatment

ASJC Scopus subject areas

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