Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis

Flora M. Vaccarino, Michael L. Schwartz, Rossana Raballo, Jon Nilsen, Julianne Rhee, Ming Zhou, Thomas Doetschman, J. Douglas Coffin, Jason J. Wyland, Yu Ting Elizabeth Hung

Research output: Contribution to journalArticle

281 Citations (Scopus)

Abstract

We show that fibroblast growth factor 2 (FGF2) and FGF receptors are transiently expressed by cells of the pseudostratified ventricular epithelium (PVE) during early neurogenesis. A single microinjection of FGF2 into cerebral ventricles of rat embryos at E15.5 increased the volume and total number of neurons in the adult cerebral cortex by 18% and 87%, respectively. Microinjection of FGF2 by the end of neurogenesis, at E20.5, selectively increased the number of glia. Mice lacking the FGF2 gene had fewer cortical neurons and gila at maturity. BrdU studies in FGF2-microinjected and FGF2- null animals suggested that FGF2 increases the proportion of dividing cells in the PVE without affecting the cell-cycle length. Thus, FGF2 increases the number of rounds of division of cortical progenitors.

Original languageEnglish (US)
Pages (from-to)246-253
Number of pages8
JournalNature Neuroscience
Volume2
Issue number3
DOIs
StatePublished - Mar 1 1999

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Fibroblast Growth Factors
Fibroblast Growth Factor 2
Cerebral Cortex
Embryonic Development
Fibroblast Growth Factor Receptors
Neurogenesis
Microinjections
Epithelium
Neurons
Cerebral Ventricles
Bromodeoxyuridine
Neuroglia
Cell Cycle
Embryonic Structures

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Vaccarino, F. M., Schwartz, M. L., Raballo, R., Nilsen, J., Rhee, J., Zhou, M., ... Hung, Y. T. E. (1999). Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis. Nature Neuroscience, 2(3), 246-253. https://doi.org/10.1038/6350

Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis. / Vaccarino, Flora M.; Schwartz, Michael L.; Raballo, Rossana; Nilsen, Jon; Rhee, Julianne; Zhou, Ming; Doetschman, Thomas; Coffin, J. Douglas; Wyland, Jason J.; Hung, Yu Ting Elizabeth.

In: Nature Neuroscience, Vol. 2, No. 3, 01.03.1999, p. 246-253.

Research output: Contribution to journalArticle

Vaccarino, FM, Schwartz, ML, Raballo, R, Nilsen, J, Rhee, J, Zhou, M, Doetschman, T, Coffin, JD, Wyland, JJ & Hung, YTE 1999, 'Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis', Nature Neuroscience, vol. 2, no. 3, pp. 246-253. https://doi.org/10.1038/6350
Vaccarino FM, Schwartz ML, Raballo R, Nilsen J, Rhee J, Zhou M et al. Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis. Nature Neuroscience. 1999 Mar 1;2(3):246-253. https://doi.org/10.1038/6350
Vaccarino, Flora M. ; Schwartz, Michael L. ; Raballo, Rossana ; Nilsen, Jon ; Rhee, Julianne ; Zhou, Ming ; Doetschman, Thomas ; Coffin, J. Douglas ; Wyland, Jason J. ; Hung, Yu Ting Elizabeth. / Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis. In: Nature Neuroscience. 1999 ; Vol. 2, No. 3. pp. 246-253.
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