@article{0360fc3cfeee4584a72d730483549d2d,
title = "Changes in dynamic resting state network connectivity following aphasia therapy",
abstract = "Resting state magnetic resonance imaging (rsfMRI) permits observation of intrinsic neural networks produced by task-independent correlations in low frequency brain activity. Various resting state networks have been described, with each thought to reflect common engagement in some shared function. There has been limited investigation of the plasticity in these network relationships after stroke or induced by therapy. Twelve individuals with language disorders after stroke (aphasia) were imaged at multiple time points before (baseline) and after an imitation-based aphasia therapy. Language assessment using a narrative production task was performed at the same time points. Group independent component analysis (ICA) was performed on the rsfMRI data to identify resting state networks. A sliding window approach was then applied to assess the dynamic nature of the correlations among these networks. Network correlations during each 30-second window were used to cluster the data into ten states for each window at each time point for each subject. Correlation was performed between changes in time spent in each state and therapeutic gains on the narrative task. The amount of time spent in a single one of the (ten overall) dynamic states was positively associated with behavioral improvement on the narrative task at the 6-week post-therapy maintenance interval, when compared with either baseline or assessment immediately following therapy. This particular state was characterized by minimal correlation among the task-independent resting state networks. Increased functional independence and segregation of resting state networks underlies improvement on a narrative production task following imitation-based aphasia treatment. This has important clinical implications for the targeting of noninvasive brain stimulation in post-stroke remediation.",
keywords = "Aphasia, Brain networks, Rehabilitation, Resting state, Speech-language pathology, Stroke, fMRI",
author = "Duncan, {E. Susan} and Small, {Steven L.}",
note = "Funding Information: Funding NIDCD grants R01-DC007488, R33-DC008638, James S. McDonnell Foundation, Mr. William Rosing. Funding Information: Acknowledgements This research was supported by the National Institute of Deafness and other Communication Disorders (NIDCD) of the National Institutes of Health (NIH) under Grants R01-DC007488 and R33-DC008638, the James S. McDonnell Foundation under a grant to the Brain Network Recovery Group (A.R. McIntosh, PI), and Mr. William Rosing, Esq. All speech and language evaluations were coordinated by Dr. Leora Cherney at the Rehabilitation Institute of Chicago (RIC), and performed by her staff at RIC. The research staff at The University of Chicago included Blythe Buchholz and Robert Fowler, who helped coordinate the project, and Dan Rodney, who authored the IMITATE software. Dr. Ana Solodkin supervised the drawing of lesion masks. The support of these individuals is gratefully acknowledged, as are the patients and families who generously participated in this research. Finally, we would like to thank one particularly astute and insightful reviewer, whose feedback we believe greatly improved this manuscript. Funding Information: This research was supported by the National Institute of Deafness and other Communication Disorders (NIDCD) of the National Institutes of Health (NIH) under Grants R01-DC007488 and R33-DC008638, the James S. McDonnell Foundation under a grant to the Brain Network Recovery Group (A.R. McIntosh, PI), and Mr. William Rosing, Esq. All speech and language evaluations were coordinated by Dr. Leora Cherney at the Rehabilitation Institute of Chicago (RIC), and performed by her staff at RIC. The research staff at The University of Chicago included Blythe Buchholz and Robert Fowler, who helped coordinate the project, and Dan Rodney, who authored the IMITATE software. Dr. Ana Solodkin supervised the drawing of lesion masks. The support of these individuals is gratefully acknowledged, as are the patients and families who generously participated in this research. Finally, we would like to thank one particularly astute and insightful reviewer, whose feedback we believe greatly improved this manuscript. NIDCD grants R01-DC007488, R33-DC008638, James S. McDonnell Foundation, Mr. William Rosing. SLS is Editor-in-Chief for Brain & Language. SD declares no conflict of interest. Publisher Copyright: {\textcopyright} 2017, Springer Science+Business Media, LLC.",
year = "2018",
month = aug,
day = "1",
doi = "10.1007/s11682-017-9771-2",
language = "English (US)",
volume = "12",
pages = "1141--1149",
journal = "Brain Imaging and Behavior",
issn = "1931-7557",
publisher = "Springer New York",
number = "4",
}