Changes in Epidemiology of Acetaminophen Overdoses in an Urban County Hospital After 20 Years

Apple Long, Melissa Magrath, Meredith Mihalopoulos, Jody A. Rule, Deepak Agrawal, Robert Haley, Kurt Kleinschmidt, William M. Lee

Research output: Contribution to journalArticlepeer-review

Abstract

INTRODUCTION: Acetaminophen (APAP) toxicity is the main cause of acute liver failure in the United States. A prior series (1992-1995) identified 71 hospitalized adults with APAP toxicity through the International Statistical Classification of Disease and Related Health Problems, 9th revision (ICD-9) code at Parkland Hospital, Dallas, TX. METHODS: We used a laboratory database search of serum APAP levels from 2011 to 2015 to identify patients with APAP toxicity in the same hospital. RESULTS: We identified 140 patients hospitalized for APAP toxicity from 27,143 APAP levels obtained; 35 required Intensive Care Unit (ICU) admission, and there were no deaths. APAP toxicity/100,000 admissions was similar between eras. DISCUSSION: APAP toxicity continues unabated after 20 years but with improved overall outcomes.

Original languageEnglish (US)
Pages (from-to)1324-1328
Number of pages5
JournalThe American Journal of Gastroenterology
Volume117
Issue number8
DOIs
StatePublished - Aug 1 2022

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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