Changes in regional coronary blood flow with hypertonic mannitol in conscious dogs

Ian Hutton; Samuel P. Marynick; David E Fixler; Gordon H. Templeton; James T. Willerson

doi:10.1093/cvr/9.1.47

Changes in regional coronary blood flow with hypertonic mannitol in conscious dogs

Ian Hutton, Samuel P. Marynick, David E Fixler, Gordon H. Templeton, James T. Willerson

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

AUTHORS' SYNOPSIS: Systemic haemodynamics and regional myocardial blood flow responses to hypertonic mannitol were studied in 10 conscious and 23 anaesthetized dogs. Mannitol infusion significantly increased regional myocardial blood flow in the conscious, intact dogs. Mannitol increased total coronary flow 20% in anaesthetized animals compared to 80% in the awake ones. In both groups mannitol exerted a significant positive inotropic effect as evidenced by increases in maximal LV dp/dt and dp/dt/ρ.These studies have also demonstrated that the intact conscious dog that has not received any sedation has an inner:outer wall left ventricular flow ratio greater than 1·0.

Original language	English (US)
Pages (from-to)	47-55
Number of pages	9
Journal	Cardiovascular Research
Volume	9
Issue number	1
DOIs	https://doi.org/10.1093/cvr/9.1.47
State	Published - Jan 1975

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

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abstract = "AUTHORS' SYNOPSIS: Systemic haemodynamics and regional myocardial blood flow responses to hypertonic mannitol were studied in 10 conscious and 23 anaesthetized dogs. Mannitol infusion significantly increased regional myocardial blood flow in the conscious, intact dogs. Mannitol increased total coronary flow 20% in anaesthetized animals compared to 80% in the awake ones. In both groups mannitol exerted a significant positive inotropic effect as evidenced by increases in maximal LV dp/dt and dp/dt/ρ.These studies have also demonstrated that the intact conscious dog that has not received any sedation has an inner:outer wall left ventricular flow ratio greater than 1·0.",

author = "Ian Hutton and Marynick, {Samuel P.} and Fixler, {David E} and Templeton, {Gordon H.} and Willerson, {James T.}",

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AU - Hutton, Ian

AU - Marynick, Samuel P.

AU - Fixler, David E

AU - Templeton, Gordon H.

AU - Willerson, James T.

PY - 1975/1

Y1 - 1975/1

N2 - AUTHORS' SYNOPSIS: Systemic haemodynamics and regional myocardial blood flow responses to hypertonic mannitol were studied in 10 conscious and 23 anaesthetized dogs. Mannitol infusion significantly increased regional myocardial blood flow in the conscious, intact dogs. Mannitol increased total coronary flow 20% in anaesthetized animals compared to 80% in the awake ones. In both groups mannitol exerted a significant positive inotropic effect as evidenced by increases in maximal LV dp/dt and dp/dt/ρ.These studies have also demonstrated that the intact conscious dog that has not received any sedation has an inner:outer wall left ventricular flow ratio greater than 1·0.

AB - AUTHORS' SYNOPSIS: Systemic haemodynamics and regional myocardial blood flow responses to hypertonic mannitol were studied in 10 conscious and 23 anaesthetized dogs. Mannitol infusion significantly increased regional myocardial blood flow in the conscious, intact dogs. Mannitol increased total coronary flow 20% in anaesthetized animals compared to 80% in the awake ones. In both groups mannitol exerted a significant positive inotropic effect as evidenced by increases in maximal LV dp/dt and dp/dt/ρ.These studies have also demonstrated that the intact conscious dog that has not received any sedation has an inner:outer wall left ventricular flow ratio greater than 1·0.

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Changes in regional coronary blood flow with hypertonic mannitol in conscious dogs

Abstract

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