Changes in the Gastric Mucosa With Aging

Amnon Sonnenberg, Robert M. Genta

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background & Aims: We aimed to characterize age-related changes in the gastric mucosa and investigate the contribution of Helicobacter pylori infection to these changes. Methods: We collected data from a large national pathology database of 895,323 subjects who underwent esophagogastroduodenoscopy with gastric biopsies from January 2008 through December 2013 at endoscopy centers throughout the United States. The prevalence of various types of gastric histopathology was expressed as percent of the total study population, stratified by sex, age, and state. Results: Over a lifetime, the gastric mucosa became abnormal in 50% of subjects. A higher proportion of people in areas with a high prevalence of H pylori infection acquired gastric abnormalities. H pylori-associated chronic active gastritis and mucosal changes caused by infection were observed in 22% of biopsies; these were the most common gastric abnormalities observed. Reactive gastropathy, which was detected in 18% of biopsies, increased with age and was the second most common factor of gastric pathology observed. Conclusions: On the basis of an analysis of biopsies collected by esophagogastroduodenoscopy in the United States, gastric abnormalities increase with age. Most pathologic conditions detected by histologic analysis are caused by H pylori infection, but the causes of many others are unknown.

Original languageEnglish (US)
Pages (from-to)2276-2281
Number of pages6
JournalClinical Gastroenterology and Hepatology
Volume13
Issue number13
DOIs
StatePublished - Dec 1 2015

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Gastric Mucosa
Stomach
Pylorus
Digestive System Endoscopy
Biopsy
Infection
Pathology
Helicobacter Infections
Gastritis
Helicobacter pylori
Endoscopy
Databases
Population

Keywords

  • Epidemiology
  • Gastric Atrophy
  • Gastritis
  • Helicobacter pylori
  • Intestinal Metaplasia

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Changes in the Gastric Mucosa With Aging. / Sonnenberg, Amnon; Genta, Robert M.

In: Clinical Gastroenterology and Hepatology, Vol. 13, No. 13, 01.12.2015, p. 2276-2281.

Research output: Contribution to journalArticle

Sonnenberg, Amnon ; Genta, Robert M. / Changes in the Gastric Mucosa With Aging. In: Clinical Gastroenterology and Hepatology. 2015 ; Vol. 13, No. 13. pp. 2276-2281.
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