Changes in venous return alter the plateau of stroke volume during dynamic exercise

K. M. Gallagher, S. A. Smith, R. G. Querry, K. H. Bryant, R. M. Welch-O'Connor, P. B. Raven

Research output: Contribution to journalArticle

Abstract

Six average fit (26 ± 2 yrs; V̇O2peak = 38 ± 1 ml·kg-1·min-1) subjects performed dynamic cycling to determine if increases or decreases in venous return affect the plateau that occurs in stroke volume during dynamic exercise. Each subject performed three bouts of exercise to volitional fatigue: control; exercise with Lower Body Negative Pressure (LBNP) of-40 mmHg [to reduce venous return (VR)]; and exercise with volume expansion (VE) to 10% of total blood volume with 6% dextran in saline [to increase VR]. Heart rate (HR, beats·min-1), cardiac output (Qc, L·min-1) and oxygen uptake (V̇O2) were measured and stroke volume (SV; ml·beat-1) was calculated (mean ± SEM). In the average fit subjects, the mean plateau of SV began at 43 ± 5% of V̇O2peak. However, the plateau of SV during LBNP (reduced VR) occurred at a greater percentage of V̇O2peak (53 ±4), while the plateau of SV during VE 10% (increased VR) occurred at a much earlier percent of V̇O2peak (7 ± 5), which was equivalent to rest. We conclude that the plateau of stroke volume that occurs during dynamic exercise to maximum was primarily determined by venous return and cardiac filling time.

Original languageEnglish (US)
JournalFASEB Journal
Volume12
Issue number5
StatePublished - Mar 20 1998

Fingerprint

stroke
Stroke Volume
Lower Body Negative Pressure
plateaus
exercise
dextran - saline drug combination
Dextrans
Blood Volume
Cardiac Output
Fatigue
Blood
Heart Rate
Fatigue of materials
blood volume
Oxygen
dextran
cardiac output
Scanning electron microscopy
heart rate
oxygen

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Gallagher, K. M., Smith, S. A., Querry, R. G., Bryant, K. H., Welch-O'Connor, R. M., & Raven, P. B. (1998). Changes in venous return alter the plateau of stroke volume during dynamic exercise. FASEB Journal, 12(5).

Changes in venous return alter the plateau of stroke volume during dynamic exercise. / Gallagher, K. M.; Smith, S. A.; Querry, R. G.; Bryant, K. H.; Welch-O'Connor, R. M.; Raven, P. B.

In: FASEB Journal, Vol. 12, No. 5, 20.03.1998.

Research output: Contribution to journalArticle

Gallagher, KM, Smith, SA, Querry, RG, Bryant, KH, Welch-O'Connor, RM & Raven, PB 1998, 'Changes in venous return alter the plateau of stroke volume during dynamic exercise', FASEB Journal, vol. 12, no. 5.
Gallagher, K. M. ; Smith, S. A. ; Querry, R. G. ; Bryant, K. H. ; Welch-O'Connor, R. M. ; Raven, P. B. / Changes in venous return alter the plateau of stroke volume during dynamic exercise. In: FASEB Journal. 1998 ; Vol. 12, No. 5.
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