Changing brain networks through non-invasive neuromodulation

Wing Ting To, Dirk De Ridder, John Hart, Sven Vanneste

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background/Objective: Non-invasive neuromodulation techniques, such as repetitive Transcranial Magnetic Stimulation (rTMS) and transcranial Direct Current Stimulation (tDCS), have increasingly been investigated for their potential as treatments for neurological and psychiatric disorders. Despite widespread dissemination of these techniques, the underlying therapeutic mechanisms and the ideal stimulation site for a given disorder remain unknown. Increasing evidence support the possibility of non-invasive neuromodulation affecting a brain network rather than just the local stimulation target. In this article, we present evidence in a clinical setting to support the idea that non-invasive neuromodulation changes brain networks. Method: This article addresses the idea that non-invasive neuromodulation modulates brain networks, rather than just the local stimulation target, using neuromodulation studies in tinnitus and major depression as examples. We present studies that support this hypothesis from different perspectives. Main Results/Conclusion: Studies stimulating the same brain region, such as the dorsolateral prefrontal cortex (DLPFC), have shown to be effective for several disorders and studies using different stimulation sites for the same disorder have shown similar results. These findings, as well as results from studies investigating brain network connectivity on both macro and micro levels, suggest that non-invasive neuromodulation affects a brain network rather than just the local stimulation site targeted. We propose that non-invasive neuromodulation should be approached from a network perspective and emphasize the therapeutic potential of this approach through the modulation of targeted brain networks.

Original languageEnglish (US)
Article number128
JournalFrontiers in Human Neuroscience
Volume12
DOIs
StatePublished - Apr 13 2018

Fingerprint

Brain
Tinnitus
Transcranial Magnetic Stimulation
Prefrontal Cortex
Nervous System Diseases
Psychiatry
Therapeutics
Depression

Keywords

  • Brain hubs
  • Brain networks
  • Stimulation target
  • Transcranial direct current stimulation
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Changing brain networks through non-invasive neuromodulation. / To, Wing Ting; De Ridder, Dirk; Hart, John; Vanneste, Sven.

In: Frontiers in Human Neuroscience, Vol. 12, 128, 13.04.2018.

Research output: Contribution to journalArticle

To, Wing Ting ; De Ridder, Dirk ; Hart, John ; Vanneste, Sven. / Changing brain networks through non-invasive neuromodulation. In: Frontiers in Human Neuroscience. 2018 ; Vol. 12.
@article{5c35bd6a70924f6681d61865409e2dc4,
title = "Changing brain networks through non-invasive neuromodulation",
abstract = "Background/Objective: Non-invasive neuromodulation techniques, such as repetitive Transcranial Magnetic Stimulation (rTMS) and transcranial Direct Current Stimulation (tDCS), have increasingly been investigated for their potential as treatments for neurological and psychiatric disorders. Despite widespread dissemination of these techniques, the underlying therapeutic mechanisms and the ideal stimulation site for a given disorder remain unknown. Increasing evidence support the possibility of non-invasive neuromodulation affecting a brain network rather than just the local stimulation target. In this article, we present evidence in a clinical setting to support the idea that non-invasive neuromodulation changes brain networks. Method: This article addresses the idea that non-invasive neuromodulation modulates brain networks, rather than just the local stimulation target, using neuromodulation studies in tinnitus and major depression as examples. We present studies that support this hypothesis from different perspectives. Main Results/Conclusion: Studies stimulating the same brain region, such as the dorsolateral prefrontal cortex (DLPFC), have shown to be effective for several disorders and studies using different stimulation sites for the same disorder have shown similar results. These findings, as well as results from studies investigating brain network connectivity on both macro and micro levels, suggest that non-invasive neuromodulation affects a brain network rather than just the local stimulation site targeted. We propose that non-invasive neuromodulation should be approached from a network perspective and emphasize the therapeutic potential of this approach through the modulation of targeted brain networks.",
keywords = "Brain hubs, Brain networks, Stimulation target, Transcranial direct current stimulation, Transcranial magnetic stimulation",
author = "To, {Wing Ting} and {De Ridder}, Dirk and John Hart and Sven Vanneste",
year = "2018",
month = "4",
day = "13",
doi = "10.3389/fnhum.2018.00128",
language = "English (US)",
volume = "12",
journal = "Frontiers in Human Neuroscience",
issn = "1662-5161",
publisher = "Frontiers Research Foundation",

}

TY - JOUR

T1 - Changing brain networks through non-invasive neuromodulation

AU - To, Wing Ting

AU - De Ridder, Dirk

AU - Hart, John

AU - Vanneste, Sven

PY - 2018/4/13

Y1 - 2018/4/13

N2 - Background/Objective: Non-invasive neuromodulation techniques, such as repetitive Transcranial Magnetic Stimulation (rTMS) and transcranial Direct Current Stimulation (tDCS), have increasingly been investigated for their potential as treatments for neurological and psychiatric disorders. Despite widespread dissemination of these techniques, the underlying therapeutic mechanisms and the ideal stimulation site for a given disorder remain unknown. Increasing evidence support the possibility of non-invasive neuromodulation affecting a brain network rather than just the local stimulation target. In this article, we present evidence in a clinical setting to support the idea that non-invasive neuromodulation changes brain networks. Method: This article addresses the idea that non-invasive neuromodulation modulates brain networks, rather than just the local stimulation target, using neuromodulation studies in tinnitus and major depression as examples. We present studies that support this hypothesis from different perspectives. Main Results/Conclusion: Studies stimulating the same brain region, such as the dorsolateral prefrontal cortex (DLPFC), have shown to be effective for several disorders and studies using different stimulation sites for the same disorder have shown similar results. These findings, as well as results from studies investigating brain network connectivity on both macro and micro levels, suggest that non-invasive neuromodulation affects a brain network rather than just the local stimulation site targeted. We propose that non-invasive neuromodulation should be approached from a network perspective and emphasize the therapeutic potential of this approach through the modulation of targeted brain networks.

AB - Background/Objective: Non-invasive neuromodulation techniques, such as repetitive Transcranial Magnetic Stimulation (rTMS) and transcranial Direct Current Stimulation (tDCS), have increasingly been investigated for their potential as treatments for neurological and psychiatric disorders. Despite widespread dissemination of these techniques, the underlying therapeutic mechanisms and the ideal stimulation site for a given disorder remain unknown. Increasing evidence support the possibility of non-invasive neuromodulation affecting a brain network rather than just the local stimulation target. In this article, we present evidence in a clinical setting to support the idea that non-invasive neuromodulation changes brain networks. Method: This article addresses the idea that non-invasive neuromodulation modulates brain networks, rather than just the local stimulation target, using neuromodulation studies in tinnitus and major depression as examples. We present studies that support this hypothesis from different perspectives. Main Results/Conclusion: Studies stimulating the same brain region, such as the dorsolateral prefrontal cortex (DLPFC), have shown to be effective for several disorders and studies using different stimulation sites for the same disorder have shown similar results. These findings, as well as results from studies investigating brain network connectivity on both macro and micro levels, suggest that non-invasive neuromodulation affects a brain network rather than just the local stimulation site targeted. We propose that non-invasive neuromodulation should be approached from a network perspective and emphasize the therapeutic potential of this approach through the modulation of targeted brain networks.

KW - Brain hubs

KW - Brain networks

KW - Stimulation target

KW - Transcranial direct current stimulation

KW - Transcranial magnetic stimulation

UR - http://www.scopus.com/inward/record.url?scp=85046885367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046885367&partnerID=8YFLogxK

U2 - 10.3389/fnhum.2018.00128

DO - 10.3389/fnhum.2018.00128

M3 - Article

C2 - 29706876

AN - SCOPUS:85046885367

VL - 12

JO - Frontiers in Human Neuroscience

JF - Frontiers in Human Neuroscience

SN - 1662-5161

M1 - 128

ER -