Five infants with E. coli meningitis failed to respond to kanamycin therapy. Review of kanamycin susceptibilities of E. coli isolated from blood cultures of neonates at Parkland Memorial Hospital revealed 6 per cent resistance from 1963 to 1968, and 27 per cent resistance during the past 3 years. The antimicrobial susceptibilities of 520 E. coli from 7 nurseries in North America were studied. A significant number of strains were resistant to kanamycin, streptomycin, and ampicillin: kanamycin, 14 to 34 per cent (mean 27 per cent); streptomycin, 20 to 50 per cent (mean 34 per cent); and ampicillin, 7 to 35 per cent (mean 23 per cent). In contrast, 0 to 8 per cent (mean 4 per cent) of E. coli were resistant to gentamicin and 0 to 13 per cent (mean 5 per cent) to polymyxin B.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health