@inbook{650a48bca85947cfb93c4b0e25c86ba1,
title = "Chapter 1: General Synthetic and Physical Methods",
abstract = "Contrast agents for magnetic resonance imaging (MRI) currently used and approved by the Food and Drug Administration (FDA) of the United States of America are GdIII-based. Yet, GdIII complexes are only one class of contrast agents for MRI. The fundamentals described in this chapter are intended to assist with the design of future imaging agents for MRI. Ligands affect not only relaxivity but also thermodynamic stability and kinetic inertness of GdIII complexes, which in turn affect the safety profiles of contrast agents. Divided into four sections, this chapter describes syntheses and characterization of ligands and metal complexes as well as the determination of the stability and lability of metal complexes.",
author = "Do, {Quyen N.} and Ratnakar, {James S.} and Zolt{\'a}n Kov{\'a}cs and Gyula Tircs{\'o} and {Kriszti{\'a}n K{\'a}lm{\'a}n}, Ferenc and Zsolt Baranyai and Erno Br{\"u}cher and Imre T{\'o}th",
note = "Funding Information: The authors thank the Hungarian Scientific Research Fund (NKFIH K-120224 project). The writing of this book chapter was supported by the J{\'a}nos Bolyai Research Scholarship of the Hungarian Academy of Sciences (G.T. and F.K.K.), the EU and co-financed by the European Regional Development Fund under the project GINOP-2.3.2-15-2016-00008 as well as the COST CA15209 {\textquoteleft}{\textquoteleft}European Network on NMR Relaxometry{\textquoteright}{\textquoteright} Action. Special thanks go to Prof. Michel Meyer (ICMUB, Dijon, France) for sharing the information concerning apparent constant and for reviewing the corresponding part in the chapter. F.K.K. and G.T. are also thankful for support from the Le Studium – Loire Valley Institute for Advanced Studies. Funding Information: The authors thank the Hungarian Scientific Research Fund (K-120224 project). The writing of this book chapter was supported by the J{\'a}nos Bolyai Research Scholarship of the Hungarian Academy of Sciences (G.T. and F.K.K.), the EU and co-financed by the European Regional Development Fund under the project GINOP-2.3.2-15-2016-00008 as well as the COST CA15209 {\textquoteleft}{\textquoteleft}European Network on NMR Relaxometry{\textquoteright}{\textquoteright} Action. F.K.K. and G.T. are also thankful for support from the Le Studium – Loire Valley Institute for Advanced Studies. Special thanks go to Prof. Dr Sophie Laurent for granting access to Figure 1.29. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2018.",
year = "2018",
doi = "10.1039/9781788010146-00001",
language = "English (US)",
isbn = "9781788010863",
series = "New Developments in NMR",
publisher = "Royal Society of Chemistry",
number = "13",
pages = "1--120",
editor = "Pierre, {Valerie C.} and Allen, {Matthew J.}",
booktitle = "New Developments in NMR",
address = "United Kingdom",
edition = "13",
}