Chapter 1: General Synthetic and Physical Methods

Quyen N. Do, James S. Ratnakar, Zoltán Kovács, Gyula Tircsó, Ferenc Krisztián Kálmán, Zsolt Baranyai, Erno Brücher, Imre Tóth

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Contrast agents for magnetic resonance imaging (MRI) currently used and approved by the Food and Drug Administration (FDA) of the United States of America are GdIII-based. Yet, GdIII complexes are only one class of contrast agents for MRI. The fundamentals described in this chapter are intended to assist with the design of future imaging agents for MRI. Ligands affect not only relaxivity but also thermodynamic stability and kinetic inertness of GdIII complexes, which in turn affect the safety profiles of contrast agents. Divided into four sections, this chapter describes syntheses and characterization of ligands and metal complexes as well as the determination of the stability and lability of metal complexes.

Original languageEnglish (US)
Title of host publicationNew Developments in NMR
PublisherRoyal Society of Chemistry
Pages1-120
Number of pages120
Volume2018-January
Edition13
DOIs
StatePublished - Jan 1 2018

Publication series

NameNew Developments in NMR
Number13
Volume2018-January
ISSN (Print)2044-253X
ISSN (Electronic)2044-2548

ASJC Scopus subject areas

  • Analytical Chemistry
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

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    Do, Q. N., Ratnakar, J. S., Kovács, Z., Tircsó, G., Krisztián Kálmán, F., Baranyai, Z., Brücher, E., & Tóth, I. (2018). Chapter 1: General Synthetic and Physical Methods. In New Developments in NMR (13 ed., Vol. 2018-January, pp. 1-120). (New Developments in NMR; Vol. 2018-January, No. 13). Royal Society of Chemistry. https://doi.org/10.1039/9781788010146-00001